1 Ocak 2021 Dergi makalesi Açık Erişim

Karaman, Yasemin; Kaya-Yasar, Yesim; Bozkurt, Turgut Emrah; Sahin-Erdemli, Inci

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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Karaman, Yasemin</dc:creator>
  <dc:creator>Kaya-Yasar, Yesim</dc:creator>
  <dc:creator>Bozkurt, Turgut Emrah</dc:creator>
  <dc:creator>Sahin-Erdemli, Inci</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>We aimed to investigate and compare the effects of rapid (NaHS) and slow (GYY4137 and AP39) hydrogen sulfide (H2S) releasing donors on LPS-induced tracheal hyperreactivity and pro-inflammatory cytokine levels in lung tissues of mice. Tissues were isolated from male BALB/c mice and incubated with LPS (10 mu g/mL) in tissue culture. The subgroups were incubated with NaHS, GYY4137 and mitochondria-targeted donor AP39. LPS incubation did not alter contraction response to carbachol, but enhanced 5-HT and bradykinin-induced contractions in tracheal rings, and elevated IL-1 beta, IL-6 and TNF-alpha levels in lung homogenates. NaHS at 300 mu mol/L and 1000 mu mol/L, GYY4137 at 30 mu mol/L and 100 mu mol/L, and AP39 at 30 nmol/L concentrations inhibited the tracheal hyperreactivity to 5-HT, whereas none of these donors affected the enhanced contraction to bradykinin. GYY4137 was also effective to inhibit 5-HT hyperreactivity acutely. In lung tissues, NaHS prevented the elevation of IL-1 beta level at 1000 mu mol/L, and IL-6 and TNF-alpha levels at 100 mu mol/L concentrations. Incubation with GYY4137 (100 mu mol/L) and AP39 (30 nmol/L and 300 nmol/L) inhibited the increase in IL-6 and TNF-alpha levels, but not IL-1 beta at concentrations that they affected tracheal hyperreactivity. These results indicate that H2S donors can decrease inflammation and prevent airway hyperreactivity.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/239230</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:239230</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BASIC &amp; CLINICAL PHARMACOLOGY &amp; TOXICOLOGY 128(5) 652-660</dc:source>
  <dc:title>Hydrogen sulfide donors prevent lipopolysaccharide-induced airway hyperreactivity in an in vitro model of chronic inflammation in mice</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>