1 Ocak 2021 Dergi makalesi Açık Erişim

Karaman, Yasemin; Kaya-Yasar, Yesim; Bozkurt, Turgut Emrah; Sahin-Erdemli, Inci

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/239230</identifier>
  <creators>
    <creator>
      <creatorName>Karaman, Yasemin</creatorName>
      <givenName>Yasemin</givenName>
      <familyName>Karaman</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya-Yasar, Yesim</creatorName>
      <givenName>Yesim</givenName>
      <familyName>Kaya-Yasar</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Pharmacol, Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozkurt, Turgut Emrah</creatorName>
      <givenName>Turgut Emrah</givenName>
      <familyName>Bozkurt</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sahin-Erdemli, Inci</creatorName>
      <givenName>Inci</givenName>
      <familyName>Sahin-Erdemli</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Hydrogen Sulfide Donors Prevent Lipopolysaccharide-Induced Airway Hyperreactivity In An In Vitro Model Of Chronic Inflammation In Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/239230</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1111/bcpt.13551</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">We aimed to investigate and compare the effects of rapid (NaHS) and slow (GYY4137 and AP39) hydrogen sulfide (H2S) releasing donors on LPS-induced tracheal hyperreactivity and pro-inflammatory cytokine levels in lung tissues of mice. Tissues were isolated from male BALB/c mice and incubated with LPS (10 mu g/mL) in tissue culture. The subgroups were incubated with NaHS, GYY4137 and mitochondria-targeted donor AP39. LPS incubation did not alter contraction response to carbachol, but enhanced 5-HT and bradykinin-induced contractions in tracheal rings, and elevated IL-1 beta, IL-6 and TNF-alpha levels in lung homogenates. NaHS at 300 mu mol/L and 1000 mu mol/L, GYY4137 at 30 mu mol/L and 100 mu mol/L, and AP39 at 30 nmol/L concentrations inhibited the tracheal hyperreactivity to 5-HT, whereas none of these donors affected the enhanced contraction to bradykinin. GYY4137 was also effective to inhibit 5-HT hyperreactivity acutely. In lung tissues, NaHS prevented the elevation of IL-1 beta level at 1000 mu mol/L, and IL-6 and TNF-alpha levels at 100 mu mol/L concentrations. Incubation with GYY4137 (100 mu mol/L) and AP39 (30 nmol/L and 300 nmol/L) inhibited the increase in IL-6 and TNF-alpha levels, but not IL-1 beta at concentrations that they affected tracheal hyperreactivity. These results indicate that H2S donors can decrease inflammation and prevent airway hyperreactivity.</description>
  </descriptions>
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