1 Ocak 2021 Dergi makalesi Açık Erişim

Karaman, Yasemin; Kaya-Yasar, Yesim; Bozkurt, Turgut Emrah; Sahin-Erdemli, Inci

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    "creators": [
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Karaman, Yasemin"
      }, 
      {
        "affiliation": "Karadeniz Tech Univ, Fac Pharm, Dept Pharmacol, Trabzon, Turkey", 
        "name": "Kaya-Yasar, Yesim"
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Bozkurt, Turgut Emrah"
      }, 
      {
        "affiliation": "Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey", 
        "name": "Sahin-Erdemli, Inci"
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    "description": "We aimed to investigate and compare the effects of rapid (NaHS) and slow (GYY4137 and AP39) hydrogen sulfide (H2S) releasing donors on LPS-induced tracheal hyperreactivity and pro-inflammatory cytokine levels in lung tissues of mice. Tissues were isolated from male BALB/c mice and incubated with LPS (10 mu g/mL) in tissue culture. The subgroups were incubated with NaHS, GYY4137 and mitochondria-targeted donor AP39. LPS incubation did not alter contraction response to carbachol, but enhanced 5-HT and bradykinin-induced contractions in tracheal rings, and elevated IL-1 beta, IL-6 and TNF-alpha levels in lung homogenates. NaHS at 300 mu mol/L and 1000 mu mol/L, GYY4137 at 30 mu mol/L and 100 mu mol/L, and AP39 at 30 nmol/L concentrations inhibited the tracheal hyperreactivity to 5-HT, whereas none of these donors affected the enhanced contraction to bradykinin. GYY4137 was also effective to inhibit 5-HT hyperreactivity acutely. In lung tissues, NaHS prevented the elevation of IL-1 beta level at 1000 mu mol/L, and IL-6 and TNF-alpha levels at 100 mu mol/L concentrations. Incubation with GYY4137 (100 mu mol/L) and AP39 (30 nmol/L and 300 nmol/L) inhibited the increase in IL-6 and TNF-alpha levels, but not IL-1 beta at concentrations that they affected tracheal hyperreactivity. These results indicate that H2S donors can decrease inflammation and prevent airway hyperreactivity.", 
    "doi": "10.1111/bcpt.13551", 
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    "journal": {
      "issue": "5", 
      "pages": "652-660", 
      "title": "BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY", 
      "volume": "128"
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    "license": {
      "id": "cc-by"
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    "publication_date": "2021-01-01", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Di\u011fer"
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    "title": "Hydrogen sulfide donors prevent lipopolysaccharide-induced airway hyperreactivity in an in vitro model of chronic inflammation in mice"
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