1 Ocak 2021 Dergi makalesi Açık Erişim

Kig, Cenk; Mertoglu, Elif; Caliskan, Alper; Agus, Hizlan Hincal; Ucar, Evren Onay; Guler, Varol

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/237100</identifier>
  <creators>
    <creator>
      <creatorName>Kig, Cenk</creatorName>
      <givenName>Cenk</givenName>
      <familyName>Kig</familyName>
      <affiliation>Istanbul Yeni Yuzyil Univ, Fac Med, Dept Med Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Mertoglu, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Mertoglu</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Caliskan, Alper</creatorName>
      <givenName>Alper</givenName>
      <familyName>Caliskan</familyName>
      <affiliation>Istanbul Univ, Inst Grad Studies Sci, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Agus, Hizlan Hincal</creatorName>
      <givenName>Hizlan Hincal</givenName>
      <familyName>Agus</familyName>
      <affiliation>Istanbul Yeni Yuzyil Univ, Fac Arts &amp; Sci, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ucar, Evren Onay</creatorName>
      <givenName>Evren Onay</givenName>
      <familyName>Ucar</familyName>
      <affiliation>Istanbul Univ, Fac Sci, Dept Mol Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Varol</creatorName>
      <givenName>Varol</givenName>
      <familyName>Guler</familyName>
      <affiliation>Istanbul Yeni Yuzyil Univ, Fac Med, Dept Med Biol &amp; Genet, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Selective And Oxidative Stress-Mediated Cell Death Of Mcf-7 Cell Line Induced By Terpinolene</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/237100</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11756-021-00803-z</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, we compared the effects of terpinolene against the anti-cancer agent cisplatin on proliferation, apoptotic activity and intracellular ROS (reactive oxygen species) production in cancerous (MCF-7) and non-cancerous (HEK-293) cell lines. Cisplatin presented a strong growth-inhibitory effect on both MCF-7 (IC25: 18.77 mu M) and HEK-293 (IC25: 15.03 mu M) cell lines. The growth-inhibitory effect of terpinolene was found to be weaker than cisplatin (IC25: 291.18 mu M for MCF-7 and 345.35 mu M for HEK 293 cells). The expression levels of BAX (by 1.86-fold), cleaved-PARP (by 2.23-fold) and pro-caspase-8 (by 1.74-fold) proteins increased in response to terpinolene treatment in MCF-7 cells. Curiously, the increase in the expression levels of these apoptotic markers was less pronounced in terpinolene-treated non-cancerous HEK 293 cells. Terpinolene, promoted a higher rate of apoptotic and necrotic cell death on MCF-7 cells (apoptotic cells: 25.28 %; necrotic cells: 17.70 %) when compared with HEK-293 cell line (apoptotic cells: 15.47 %; necrotic cells: 9.42 %). Interestingly, terpinolene caused a marked increase (2.05-fold) in intracellular ROS production in MCF-7 cells while HEK-293 cells appeared to be resistant to terpinolene or cisplatin treatments. In conclusion, although terpinolene showed a weaker growth-inhibitory effect on MCF-7 cancer cells, it exhibited a better selectivity than cisplatin in inducing cell death and intracellular oxidative stress in MCF7 breast cancer cells.</description>
  </descriptions>
</resource>