1 Ocak 2021 Dergi makalesi Açık Erişim

Ak Aksoy, Secil; Mutlu, Melis; Tunca, Berrin; Kocaeli, Hasan; Taskapilioglu, Mevlut Ozgur; Bekar, Ahmet; Tekin, Cagla; Argadal, Omer Gokay; Civan, Muhammet Nafi; Kaya, Ismail Seckin; Ocak, Pinar Eser; Tolunay, Sahsine

Dublin Core

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Ak Aksoy, Secil</dc:creator>
  <dc:creator>Mutlu, Melis</dc:creator>
  <dc:creator>Tunca, Berrin</dc:creator>
  <dc:creator>Kocaeli, Hasan</dc:creator>
  <dc:creator>Taskapilioglu, Mevlut Ozgur</dc:creator>
  <dc:creator>Bekar, Ahmet</dc:creator>
  <dc:creator>Tekin, Cagla</dc:creator>
  <dc:creator>Argadal, Omer Gokay</dc:creator>
  <dc:creator>Civan, Muhammet Nafi</dc:creator>
  <dc:creator>Kaya, Ismail Seckin</dc:creator>
  <dc:creator>Ocak, Pinar Eser</dc:creator>
  <dc:creator>Tolunay, Sahsine</dc:creator>
  <dc:date>2021-01-01</dc:date>
  <dc:description>Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p &lt; 0.001, p &lt; 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p &lt; 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p &lt; 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p &lt; 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/236606</dc:identifier>
  <dc:identifier>oai:aperta.ulakbim.gov.tr:236606</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>NEUROLOGICAL RESEARCH 43(11) 916-925</dc:source>
  <dc:title>Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>