1 Ocak 2021 Dergi makalesi Açık Erişim

Ak Aksoy, Secil; Mutlu, Melis; Tunca, Berrin; Kocaeli, Hasan; Taskapilioglu, Mevlut Ozgur; Bekar, Ahmet; Tekin, Cagla; Argadal, Omer Gokay; Civan, Muhammet Nafi; Kaya, Ismail Seckin; Ocak, Pinar Eser; Tolunay, Sahsine

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/236606</identifier>
  <creators>
    <creator>
      <creatorName>Ak Aksoy, Secil</creatorName>
      <givenName>Secil</givenName>
      <familyName>Ak Aksoy</familyName>
      <affiliation>Bursa Uludag Univ, Inegol Vocat Sch, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Mutlu, Melis</creatorName>
      <givenName>Melis</givenName>
      <familyName>Mutlu</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunca, Berrin</creatorName>
      <givenName>Berrin</givenName>
      <familyName>Tunca</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kocaeli, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Kocaeli</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Taskapilioglu, Mevlut Ozgur</creatorName>
      <givenName>Mevlut Ozgur</givenName>
      <familyName>Taskapilioglu</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bekar, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Bekar</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekin, Cagla</creatorName>
      <givenName>Cagla</givenName>
      <familyName>Tekin</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Argadal, Omer Gokay</creatorName>
      <givenName>Omer Gokay</givenName>
      <familyName>Argadal</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Civan, Muhammet Nafi</creatorName>
      <givenName>Muhammet Nafi</givenName>
      <familyName>Civan</familyName>
      <affiliation>Uludag Univ, Fac Med, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya, Ismail Seckin</creatorName>
      <givenName>Ismail Seckin</givenName>
      <familyName>Kaya</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ocak, Pinar Eser</creatorName>
      <givenName>Pinar Eser</givenName>
      <familyName>Ocak</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tolunay, Sahsine</creatorName>
      <givenName>Sahsine</givenName>
      <familyName>Tolunay</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Pathol, Bursa, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Coexistence Of Tert C228T Mutation And Malat1 Dysregulation In Primary Glioblastoma: New Prognostic And Therapeutic Targets</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/236606</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/01616412.2021.1948738</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p &amp;lt; 0.001, p &amp;lt; 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p &amp;lt; 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p &amp;lt; 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p &amp;lt; 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies.</description>
  </descriptions>
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