1 Ocak 2021 Dergi makalesi Açık Erişim

Ak Aksoy, Secil; Mutlu, Melis; Tunca, Berrin; Kocaeli, Hasan; Taskapilioglu, Mevlut Ozgur; Bekar, Ahmet; Tekin, Cagla; Argadal, Omer Gokay; Civan, Muhammet Nafi; Kaya, Ismail Seckin; Ocak, Pinar Eser; Tolunay, Sahsine

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{
  "@context": "https://schema.org/", 
  "@id": 236606, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Inegol Vocat Sch, Bursa, Turkey", 
      "name": "Ak Aksoy, Secil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey", 
      "name": "Mutlu, Melis"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey", 
      "name": "Tunca, Berrin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Kocaeli, Hasan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Taskapilioglu, Mevlut Ozgur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Bekar, Ahmet"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Med Biol, Bursa, Turkey", 
      "name": "Tekin, Cagla"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Argadal, Omer Gokay"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Uludag Univ, Fac Med, Bursa, Turkey", 
      "name": "Civan, Muhammet Nafi"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Kaya, Ismail Seckin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Neurosurg, Bursa, Turkey", 
      "name": "Ocak, Pinar Eser"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bursa Uludag Univ, Fac Med, Dept Pathol, Bursa, Turkey", 
      "name": "Tolunay, Sahsine"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Objective: This study was designed to conduct molecular classification based on IDH1/2, TERT, ATRX, and DAXX changes in pediatric and adult primary glioblastoma (GB) and to analyze the potential interaction of LncRNA MALAT1 in the determined homogeneous subgroups. Methods: We analyzed the expression profiles of ATRX/DAXX and MALAT1 using the qRT-PCR method and IDH and TERT mutation status using DNA sequencing analysis in 85 primary pediatric and adult GB patients. Results: IDH1 mutation was observed in 5 (5.88%) and TERT mutation in 65 (76.47%) primary pediatric and adult GB patients. ATRX and DAXX were detected in 18 (21.18%) and 7 (8.24%) patients. TERT mutation and loss of ATRX/DAXX were associated with short overall survival (p < 0.001, p < 0.001, respectively). Patients carrying especially TERT C228T mutation had worse prognosis (p < 0.001). Six subgroups were obtained from the genetic analysis. Among the subgroups, MALAT1 was highly expressed in group A that had a single TERT mutation as compared to that in groups D and E (p = 0.001 and p < 0.001, respectively); further, high MALAT1 expression was associated with worse prognosis in patients with C228T mutation (p < 0.001). Conclusions: Our findings highlight that the presence of TERT C228T mutation and expression of MALAT1 can be used as primary targets during the follow-up of primary GB patients and in the development of new treatment strategies.", 
  "headline": "Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets", 
  "identifier": 236606, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Coexistence of TERT C228T mutation and MALAT1 dysregulation in primary glioblastoma: new prognostic and therapeutic targets", 
  "url": "https://aperta.ulakbim.gov.tr/record/236606"
}