1 Ocak 2021 Dergi makalesi Açık Erişim

Yakubogullari, Nilgun; Coven, Furkan Ozan; Cebi, Nusin; Coven, Fethiye; Coven, Nejdet; Genc, Rukan; Bedir, Erdal; Nalbantsoy, Ayse

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    "creators": [
      {
        "affiliation": "Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35433 Izmir, Turkey", 
        "name": "Yakubogullari, Nilgun"
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      {
        "affiliation": "Manisa Celal Bayar Univ, Fac Engn, Dept Bioengn, TR-45140 Manisa, Turkey", 
        "name": "Coven, Furkan Ozan"
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      {
        "affiliation": "Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey", 
        "name": "Cebi, Nusin"
      }, 
      {
        "affiliation": "Bornova Vet Control Inst, TR-35100 Izmir, Turkey", 
        "name": "Coven, Fethiye"
      }, 
      {
        "affiliation": "Bornova Vet Control Inst, TR-35100 Izmir, Turkey", 
        "name": "Coven, Nejdet"
      }, 
      {
        "affiliation": "Mersin Univ, Fac Engn, Dept Chem Engn, TR-33343 Mersin, Turkey", 
        "name": "Genc, Rukan"
      }, 
      {
        "affiliation": "Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35433 Izmir, Turkey", 
        "name": "Bedir, Erdal"
      }, 
      {
        "affiliation": "Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey", 
        "name": "Nalbantsoy, Ayse"
      }
    ], 
    "description": "Astragaloside VII (AST-VII), a major cycloartane saponin isolated from Turkish Astragalus species, turned out to be one of the most active metabolites demonstrating Th1/Th2 balanced immune response. As Quillaja saponins are extensively used in adjuvant systems, this study made an attempt to improve AST-VII based adjuvant systems by using different immunostimulatory/delivery agents (monophosphoryllipid A (MPL), Astragalus polysaccharide (APS) and squalene) and to induce cellular and humoral immune response against a viral vaccine. For this purpose, Newcastle Disease vaccine (NDV) was chosen as a model vaccine. Swiss albino mice were immunized subcutaneously with LaSota vaccines in the presence/absence of AST-VII or developed adjuvant systems. AST-VII administration both in live/inactivated LaSota vaccines induced neutralizing and NDV specific IgG, IgG1 and IgG2b antibodies response as well as IL-2 and IL-4 production. APS based delivery systems enhanced the production of neutralizing antibody and the minor augmentation of IFN-? and IL-2 levels. Squalene emulsion (SE) alone or combined with AST-VII were effective in NDV restimulated splenocyte proliferation. As a conclusion, AST-VII and AST-VII containing adjuvant systems demonstrated Th1/Th2 balanced antibody and cellular immune responses in NDV vaccines. Thus, these systems could be developed as vaccine adjuvants in viral vaccines as alternative to saponin-based adjuvants.", 
    "doi": "10.1016/j.biologicals.2021.01.005", 
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    "journal": {
      "pages": "28-37", 
      "title": "BIOLOGICALS", 
      "volume": "70"
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      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "science_branches": [
      "Di\u011fer"
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    "title": "Evaluation of adjuvant activity of Astragaloside VII and its combination with different immunostimulating agents in Newcastle Disease vaccine"
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