1 Ocak 2021 Dergi makalesi Açık Erişim

Yakubogullari, Nilgun; Coven, Furkan Ozan; Cebi, Nusin; Coven, Fethiye; Coven, Nejdet; Genc, Rukan; Bedir, Erdal; Nalbantsoy, Ayse

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/233224</identifier>
  <creators>
    <creator>
      <creatorName>Yakubogullari, Nilgun</creatorName>
      <givenName>Nilgun</givenName>
      <familyName>Yakubogullari</familyName>
      <affiliation>Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35433 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Coven, Furkan Ozan</creatorName>
      <givenName>Furkan Ozan</givenName>
      <familyName>Coven</familyName>
      <affiliation>Manisa Celal Bayar Univ, Fac Engn, Dept Bioengn, TR-45140 Manisa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cebi, Nusin</creatorName>
      <givenName>Nusin</givenName>
      <familyName>Cebi</familyName>
      <affiliation>Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Coven, Fethiye</creatorName>
      <givenName>Fethiye</givenName>
      <familyName>Coven</familyName>
      <affiliation>Bornova Vet Control Inst, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Coven, Nejdet</creatorName>
      <givenName>Nejdet</givenName>
      <familyName>Coven</familyName>
      <affiliation>Bornova Vet Control Inst, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Genc, Rukan</creatorName>
      <givenName>Rukan</givenName>
      <familyName>Genc</familyName>
      <affiliation>Mersin Univ, Fac Engn, Dept Chem Engn, TR-33343 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bedir, Erdal</creatorName>
      <givenName>Erdal</givenName>
      <familyName>Bedir</familyName>
      <affiliation>Izmir Inst Technol, Fac Engn, Dept Bioengn, TR-35433 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nalbantsoy, Ayse</creatorName>
      <givenName>Ayse</givenName>
      <familyName>Nalbantsoy</familyName>
      <affiliation>Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Evaluation Of Adjuvant Activity Of Astragaloside Vii And Its Combination With Different Immunostimulating Agents In Newcastle Disease Vaccine</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/233224</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.biologicals.2021.01.005</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Astragaloside VII (AST-VII), a major cycloartane saponin isolated from Turkish Astragalus species, turned out to be one of the most active metabolites demonstrating Th1/Th2 balanced immune response. As Quillaja saponins are extensively used in adjuvant systems, this study made an attempt to improve AST-VII based adjuvant systems by using different immunostimulatory/delivery agents (monophosphoryllipid A (MPL), Astragalus polysaccharide (APS) and squalene) and to induce cellular and humoral immune response against a viral vaccine. For this purpose, Newcastle Disease vaccine (NDV) was chosen as a model vaccine. Swiss albino mice were immunized subcutaneously with LaSota vaccines in the presence/absence of AST-VII or developed adjuvant systems. AST-VII administration both in live/inactivated LaSota vaccines induced neutralizing and NDV specific IgG, IgG1 and IgG2b antibodies response as well as IL-2 and IL-4 production. APS based delivery systems enhanced the production of neutralizing antibody and the minor augmentation of IFN-? and IL-2 levels. Squalene emulsion (SE) alone or combined with AST-VII were effective in NDV restimulated splenocyte proliferation. As a conclusion, AST-VII and AST-VII containing adjuvant systems demonstrated Th1/Th2 balanced antibody and cellular immune responses in NDV vaccines. Thus, these systems could be developed as vaccine adjuvants in viral vaccines as alternative to saponin-based adjuvants.</description>
  </descriptions>
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