1 Ocak 2021 Dergi makalesi Açık Erişim

Aru, Basak; Gunay, Aysel; Demirel, Gulderen Yanikkaya; Gurek, Ayse Gul; Atilla, Devrim

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{
  "@context": "https://schema.org/", 
  "@id": 230486, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Immunol Dept, Fac Med, TR-34755 Istanbul, Turkey", 
      "name": "Aru, Basak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey", 
      "name": "Gunay, Aysel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yeditepe Univ, Immunol Dept, Fac Med, TR-34755 Istanbul, Turkey", 
      "name": "Demirel, Gulderen Yanikkaya"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey", 
      "name": "Gurek, Ayse Gul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey", 
      "name": "Atilla, Devrim"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "In this study, we synthesized and characterized 3-hydroxypyridin-2-thione (3-HPT) bearing zinc (ZnPc-1 and ZnPc-2) and indium (InPc-1 and InPc-2) phthalocyanine (Pc) derivatives, either non-peripherally or peripherally substituted as photosensitizer (PS) agents and evaluated their anti-cancer efficacy on two breast cancer cell lines, MDA-MB-231 and MCF-7 as well as a human endothelial cell line, HUVEC. Our results indicated different localization patterns between ZnPcs and InPcs in addition to enhanced effects on the mitochondrial network for InPcs. Moreover, peripheral or non-peripheral substitution of HDACi moieties altered cellular localization between ZnPc-1 and ZnPc-2, leading to increased IC50 values along with decreased anti-cancer activity for non-peripheral substitution. When considering the compounds' differential effects in vitro, our data indicates that further research is required to determine the ideal Pcs for anti-cancer PDT treatments since the core metals of the compounds have affected the cellular localization, and positioning of the chemotherapeutic residues may inhibit cellular penetrance.", 
  "headline": "Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy", 
  "identifier": 230486, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy", 
  "url": "https://aperta.ulakbim.gov.tr/record/230486"
}