1 Ocak 2021 Dergi makalesi Açık Erişim

Aru, Basak; Gunay, Aysel; Demirel, Gulderen Yanikkaya; Gurek, Ayse Gul; Atilla, Devrim

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230486</identifier>
  <creators>
    <creator>
      <creatorName>Aru, Basak</creatorName>
      <givenName>Basak</givenName>
      <familyName>Aru</familyName>
      <affiliation>Yeditepe Univ, Immunol Dept, Fac Med, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunay, Aysel</creatorName>
      <givenName>Aysel</givenName>
      <familyName>Gunay</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demirel, Gulderen Yanikkaya</creatorName>
      <givenName>Gulderen Yanikkaya</givenName>
      <familyName>Demirel</familyName>
      <affiliation>Yeditepe Univ, Immunol Dept, Fac Med, TR-34755 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gurek, Ayse Gul</creatorName>
      <givenName>Ayse Gul</givenName>
      <familyName>Gurek</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Atilla, Devrim</creatorName>
      <givenName>Devrim</givenName>
      <familyName>Atilla</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Kacaeli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Evaluation Of Histone Deacetylase Inhibitor Substituted Zinc And Indium Phthalocyanines For Chemo- And Photodynamic Therapy</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230486</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/d1ra05404j</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, we synthesized and characterized 3-hydroxypyridin-2-thione (3-HPT) bearing zinc (ZnPc-1 and ZnPc-2) and indium (InPc-1 and InPc-2) phthalocyanine (Pc) derivatives, either non-peripherally or peripherally substituted as photosensitizer (PS) agents and evaluated their anti-cancer efficacy on two breast cancer cell lines, MDA-MB-231 and MCF-7 as well as a human endothelial cell line, HUVEC. Our results indicated different localization patterns between ZnPcs and InPcs in addition to enhanced effects on the mitochondrial network for InPcs. Moreover, peripheral or non-peripheral substitution of HDACi moieties altered cellular localization between ZnPc-1 and ZnPc-2, leading to increased IC50 values along with decreased anti-cancer activity for non-peripheral substitution. When considering the compounds' differential effects in vitro, our data indicates that further research is required to determine the ideal Pcs for anti-cancer PDT treatments since the core metals of the compounds have affected the cellular localization, and positioning of the chemotherapeutic residues may inhibit cellular penetrance.</description>
  </descriptions>
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