1 Ocak 2021 Dergi makalesi Açık Erişim

Aru, Basak; Gunay, Aysel; Demirel, Gulderen Yanikkaya; Gurek, Ayse Gul; Atilla, Devrim

Citation Style Language JSON

{
  "DOI": "10.1039/d1ra05404j", 
  "abstract": "In this study, we synthesized and characterized 3-hydroxypyridin-2-thione (3-HPT) bearing zinc (ZnPc-1 and ZnPc-2) and indium (InPc-1 and InPc-2) phthalocyanine (Pc) derivatives, either non-peripherally or peripherally substituted as photosensitizer (PS) agents and evaluated their anti-cancer efficacy on two breast cancer cell lines, MDA-MB-231 and MCF-7 as well as a human endothelial cell line, HUVEC. Our results indicated different localization patterns between ZnPcs and InPcs in addition to enhanced effects on the mitochondrial network for InPcs. Moreover, peripheral or non-peripheral substitution of HDACi moieties altered cellular localization between ZnPc-1 and ZnPc-2, leading to increased IC50 values along with decreased anti-cancer activity for non-peripheral substitution. When considering the compounds' differential effects in vitro, our data indicates that further research is required to determine the ideal Pcs for anti-cancer PDT treatments since the core metals of the compounds have affected the cellular localization, and positioning of the chemotherapeutic residues may inhibit cellular penetrance.", 
  "author": [
    {
      "family": "Aru", 
      "given": " Basak"
    }, 
    {
      "family": "Gunay", 
      "given": " Aysel"
    }, 
    {
      "family": "Demirel", 
      "given": " Gulderen Yanikkaya"
    }, 
    {
      "family": "Gurek", 
      "given": " Ayse Gul"
    }, 
    {
      "family": "Atilla", 
      "given": " Devrim"
    }
  ], 
  "container_title": "RSC ADVANCES", 
  "id": "230486", 
  "issue": "55", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "34963-34978", 
  "title": "Evaluation of histone deacetylase inhibitor substituted zinc and indium phthalocyanines for chemo- and photodynamic therapy", 
  "type": "article-journal", 
  "volume": "11"
}