1 Ocak 2021 Dergi makalesi Açık Erişim

Erdogar, Nazli; Akkin, Safiye; Nielsen, Thorbjorn T.; Ozcelebi, Esin; Erdogdu, Batuhan; Nemutlu, Emirhan; Iskit, Alper B.; Bilensoy, Erem

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    <subfield code="a">Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.</subfield>
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    <subfield code="u">Aalborg Univ, Dept Chem &amp; Biosci, Aalborg, Denmark</subfield>
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