1 Ocak 2021 Dergi makalesi Açık Erişim

Erdogar, Nazli; Akkin, Safiye; Nielsen, Thorbjorn T.; Ozcelebi, Esin; Erdogdu, Batuhan; Nemutlu, Emirhan; Iskit, Alper B.; Bilensoy, Erem

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/230440</identifier>
  <creators>
    <creator>
      <creatorName>Erdogar, Nazli</creatorName>
      <givenName>Nazli</givenName>
      <familyName>Erdogar</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akkin, Safiye</creatorName>
      <givenName>Safiye</givenName>
      <familyName>Akkin</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nielsen, Thorbjorn T.</creatorName>
      <givenName>Thorbjorn T.</givenName>
      <familyName>Nielsen</familyName>
      <affiliation>Aalborg Univ, Dept Chem &amp; Biosci, Aalborg, Denmark</affiliation>
    </creator>
    <creator>
      <creatorName>Ozcelebi, Esin</creatorName>
      <givenName>Esin</givenName>
      <familyName>Ozcelebi</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmacol, Fac Med, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogdu, Batuhan</creatorName>
      <givenName>Batuhan</givenName>
      <familyName>Erdogdu</familyName>
      <affiliation>Hacettepe Univ, Dept Hematol, Fac Med, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nemutlu, Emirhan</creatorName>
      <givenName>Emirhan</givenName>
      <familyName>Nemutlu</familyName>
      <affiliation>Hacettepe Univ, Dept Analyt Chem, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Iskit, Alper B.</creatorName>
      <givenName>Alper B.</givenName>
      <familyName>Iskit</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmacol, Fac Med, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bilensoy, Erem</creatorName>
      <givenName>Erem</givenName>
      <familyName>Bilensoy</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Development Of Oral Aprepitant-Loaded Chitosan-Polyethylene Glycol-Coated Cyclodextrin Nanocapsules: Formulation, Characterization, And Pharmacokinetic Evaluation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/230440</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s40005-020-00511-x</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.</description>
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