1 Ocak 2021 Dergi makalesi Açık Erişim

Erdogar, Nazli; Akkin, Safiye; Nielsen, Thorbjorn T.; Ozcelebi, Esin; Erdogdu, Batuhan; Nemutlu, Emirhan; Iskit, Alper B.; Bilensoy, Erem

Citation Style Language JSON

{
  "DOI": "10.1007/s40005-020-00511-x", 
  "abstract": "Purpose Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)-polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT.", 
  "author": [
    {
      "family": "Erdogar", 
      "given": " Nazli"
    }, 
    {
      "family": "Akkin", 
      "given": " Safiye"
    }, 
    {
      "family": "Nielsen", 
      "given": " Thorbjorn T."
    }, 
    {
      "family": "Ozcelebi", 
      "given": " Esin"
    }, 
    {
      "family": "Erdogdu", 
      "given": " Batuhan"
    }, 
    {
      "family": "Nemutlu", 
      "given": " Emirhan"
    }, 
    {
      "family": "Iskit", 
      "given": " Alper B."
    }, 
    {
      "family": "Bilensoy", 
      "given": " Erem"
    }
  ], 
  "container_title": "JOURNAL OF PHARMACEUTICAL INVESTIGATION", 
  "id": "230440", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "297-310", 
  "title": "Development of oral aprepitant-loaded chitosan-polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation", 
  "type": "article-journal", 
  "volume": "51"
}