1 Ocak 2021 Dergi makalesi Açık Erişim

Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betul; Demiray, Mutlu; Eroglu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy

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{
  "@context": "https://schema.org/", 
  "@id": 229706, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Eskandari, Zahra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "BezmialemVakif Univ, Fac Pharm, Dept Pharmaceut Biotechnol, Vatan Str Adnan Menderes Blv, TR-34093 Istanbul, Turkey", 
      "name": "Bahadori, Fatemeh"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey", 
      "name": "Yenigun, Vildan Betul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Medicana Int Istanbul Hosp, Dept Med Oncol, TR-34520 Istanbul, Turkey", 
      "name": "Demiray, Mutlu"
    }, 
    {
      "@type": "Person", 
      "name": "Eroglu, Mehmet Sayip"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey", 
      "name": "Kocyigit, Abdurrahim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Marmara Univ, Dept Bioengn, IBSB Ind Biotechnol & Syst Biol Res Grp, Goztepe Campus, TR-34722 Istanbul, Turkey", 
      "name": "Oner, Ebru Toksoy"
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Chemoresistance (CR) is one of the reasons why chemotherapy agents like Gemcitabine (GMC) remain insufficient in healing breast cancer. Activation of Nuclear Factor-kappa B (NF-kappa B) during chemotherapy is known as an important factor in the development of CR. The hydrophobic polyphenol curcumin is shown to inhibit NF-kappa B and hence CR. The aim of this work was to increase the poor bioavailability of curcumin by loading it into the nano-micelles made of Poly (Lactide-co-Glycolide) (PLGA) and levan, where levan as a natural fructose homopolymer makes the nano-micelle more stable and increases its uptake using the fructose moieties. In this study, a PLGA-levan-curcumin formulation (PLC) was designed and characterized. The size was measured as 154.16 +/- 1.45 nm with a 67.68% encapsulation efficiency (EE%). The incorporation between the components was approved. Levan made the nano-micelles stable for at least three months, increased their uptake, and led to a 10,000-fold increase in the solubility of curcumin. The enhanced bioavailability of curcumin reduced the NF-kappa B levels elevated by GMC, both in vitro and in vivo. The PLC showed a complete tumor treatment, while GMC only showed a rate of 52%. These point to the great potential of the PLC to be used simultaneously with chemotherapy.", 
  "headline": "Levan enhanced the NF-kappa B suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment", 
  "identifier": 229706, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Levan enhanced the NF-kappa B suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment", 
  "url": "https://aperta.ulakbim.gov.tr/record/229706"
}