1 Ocak 2021 Dergi makalesi Açık Erişim

Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betul; Demiray, Mutlu; Eroglu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy

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        "name": "Eskandari, Zahra"
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      {
        "affiliation": "BezmialemVakif Univ, Fac Pharm, Dept Pharmaceut Biotechnol, Vatan Str Adnan Menderes Blv, TR-34093 Istanbul, Turkey", 
        "name": "Bahadori, Fatemeh"
      }, 
      {
        "affiliation": "Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey", 
        "name": "Yenigun, Vildan Betul"
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      {
        "affiliation": "Medicana Int Istanbul Hosp, Dept Med Oncol, TR-34520 Istanbul, Turkey", 
        "name": "Demiray, Mutlu"
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      {
        "name": "Eroglu, Mehmet Sayip"
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      {
        "affiliation": "Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey", 
        "name": "Kocyigit, Abdurrahim"
      }, 
      {
        "affiliation": "Marmara Univ, Dept Bioengn, IBSB Ind Biotechnol & Syst Biol Res Grp, Goztepe Campus, TR-34722 Istanbul, Turkey", 
        "name": "Oner, Ebru Toksoy"
      }
    ], 
    "description": "Chemoresistance (CR) is one of the reasons why chemotherapy agents like Gemcitabine (GMC) remain insufficient in healing breast cancer. Activation of Nuclear Factor-kappa B (NF-kappa B) during chemotherapy is known as an important factor in the development of CR. The hydrophobic polyphenol curcumin is shown to inhibit NF-kappa B and hence CR. The aim of this work was to increase the poor bioavailability of curcumin by loading it into the nano-micelles made of Poly (Lactide-co-Glycolide) (PLGA) and levan, where levan as a natural fructose homopolymer makes the nano-micelle more stable and increases its uptake using the fructose moieties. In this study, a PLGA-levan-curcumin formulation (PLC) was designed and characterized. The size was measured as 154.16 +/- 1.45 nm with a 67.68% encapsulation efficiency (EE%). The incorporation between the components was approved. Levan made the nano-micelles stable for at least three months, increased their uptake, and led to a 10,000-fold increase in the solubility of curcumin. The enhanced bioavailability of curcumin reduced the NF-kappa B levels elevated by GMC, both in vitro and in vivo. The PLC showed a complete tumor treatment, while GMC only showed a rate of 52%. These point to the great potential of the PLC to be used simultaneously with chemotherapy.", 
    "doi": "10.1016/j.ijbiomac.2021.08.115", 
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    "journal": {
      "pages": "223-231", 
      "title": "INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES", 
      "volume": "189"
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    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "science_branches": [
      "Di\u011fer"
    ], 
    "title": "Levan enhanced the NF-kappa B suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment"
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