1 Ocak 2021 Dergi makalesi Açık Erişim

Eskandari, Zahra; Bahadori, Fatemeh; Yenigun, Vildan Betul; Demiray, Mutlu; Eroglu, Mehmet Sayip; Kocyigit, Abdurrahim; Oner, Ebru Toksoy

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{
  "DOI": "10.1016/j.ijbiomac.2021.08.115", 
  "abstract": "Chemoresistance (CR) is one of the reasons why chemotherapy agents like Gemcitabine (GMC) remain insufficient in healing breast cancer. Activation of Nuclear Factor-kappa B (NF-kappa B) during chemotherapy is known as an important factor in the development of CR. The hydrophobic polyphenol curcumin is shown to inhibit NF-kappa B and hence CR. The aim of this work was to increase the poor bioavailability of curcumin by loading it into the nano-micelles made of Poly (Lactide-co-Glycolide) (PLGA) and levan, where levan as a natural fructose homopolymer makes the nano-micelle more stable and increases its uptake using the fructose moieties. In this study, a PLGA-levan-curcumin formulation (PLC) was designed and characterized. The size was measured as 154.16 +/- 1.45 nm with a 67.68% encapsulation efficiency (EE%). The incorporation between the components was approved. Levan made the nano-micelles stable for at least three months, increased their uptake, and led to a 10,000-fold increase in the solubility of curcumin. The enhanced bioavailability of curcumin reduced the NF-kappa B levels elevated by GMC, both in vitro and in vivo. The PLC showed a complete tumor treatment, while GMC only showed a rate of 52%. These point to the great potential of the PLC to be used simultaneously with chemotherapy.", 
  "author": [
    {
      "family": "Eskandari", 
      "given": " Zahra"
    }, 
    {
      "family": "Bahadori", 
      "given": " Fatemeh"
    }, 
    {
      "family": "Yenigun", 
      "given": " Vildan Betul"
    }, 
    {
      "family": "Demiray", 
      "given": " Mutlu"
    }, 
    {
      "family": "Eroglu", 
      "given": " Mehmet Sayip"
    }, 
    {
      "family": "Kocyigit", 
      "given": " Abdurrahim"
    }, 
    {
      "family": "Oner", 
      "given": " Ebru Toksoy"
    }
  ], 
  "container_title": "INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES", 
  "id": "229706", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "page": "223-231", 
  "title": "Levan enhanced the NF-kappa B suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment", 
  "type": "article-journal", 
  "volume": "189"
}