1 Ocak 2011 Dergi makalesi Açık Erişim

Ocak, Meltem; Helbok, Anna; von Guggenberg, Elisabeth; Ozsoy, Y.; Kabasakal, Levent; Kremser, Leopold; Decristoforo, Clemens

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    <subfield code="a">Introduction: Lack of correlation between in vitro and in vivo stability is a general problem for the development of radiopeptides especially in the case of minigastrin derivatives for therapeutic applications. In this study, we compared the influence of experimental conditions on radiopeptide stability results in vitro using a model Minigastrin (MG) analogue labelled with Lu-177. Additionally, we attempted to characterize the main serum enzymatic cleavage sites by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) analysis.</subfield>
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