Dergi makalesi Açık Erişim
Ocak, Meltem; Helbok, Anna; von Guggenberg, Elisabeth; Ozsoy, Y.; Kabasakal, Levent; Kremser, Leopold; Decristoforo, Clemens
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a Lu-177-DOTA-minigastrin derivative</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">NUCLEAR MEDICINE AND BIOLOGY</subfield> <subfield code="v">38</subfield> <subfield code="n">2</subfield> <subfield code="c">171-179</subfield> </datafield> <controlfield tag="001">19493</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Introduction: Lack of correlation between in vitro and in vivo stability is a general problem for the development of radiopeptides especially in the case of minigastrin derivatives for therapeutic applications. In this study, we compared the influence of experimental conditions on radiopeptide stability results in vitro using a model Minigastrin (MG) analogue labelled with Lu-177. Additionally, we attempted to characterize the main serum enzymatic cleavage sites by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) analysis.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria</subfield> <subfield code="a">Helbok, Anna</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria</subfield> <subfield code="a">von Guggenberg, Elisabeth</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Istanbul Univ, Dept Pharmaceut Technol, Fac Pharm, TR-34116 Istanbul, Turkey</subfield> <subfield code="a">Ozsoy, Y.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Cerrahpasa Med Fac, Dept Nucl Med, TR-34098 Istanbul, Turkey</subfield> <subfield code="a">Kabasakal, Levent</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Med Univ Innsbruck, Div Clin Biochem, Prot Microanal Facil, Bioctr, A-6020 Innsbruck, Austria</subfield> <subfield code="a">Kremser, Leopold</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria</subfield> <subfield code="a">Decristoforo, Clemens</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Ocak, Meltem</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2011-01-01</subfield> </datafield> <controlfield tag="005">20210315102223.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:19493</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:faac3d4dd789087161275bb6d431affb</subfield> <subfield code="s">305</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/19493/files/bib-def2ca5c-e860-478f-90d8-862ad9eca3a9.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.nucmedbio.2010.07.009</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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