1 Ocak 2011 Dergi makalesi Açık Erişim

Ocak, Meltem; Helbok, Anna; von Guggenberg, Elisabeth; Ozsoy, Y.; Kabasakal, Levent; Kremser, Leopold; Decristoforo, Clemens

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  "@id": 19493, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Ocak, Meltem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria", 
      "name": "Helbok, Anna"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria", 
      "name": "von Guggenberg, Elisabeth"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ, Dept Pharmaceut Technol, Fac Pharm, TR-34116 Istanbul, Turkey", 
      "name": "Ozsoy, Y."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Cerrahpasa Med Fac, Dept Nucl Med, TR-34098 Istanbul, Turkey", 
      "name": "Kabasakal, Levent"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Med Univ Innsbruck, Div Clin Biochem, Prot Microanal Facil, Bioctr, A-6020 Innsbruck, Austria", 
      "name": "Kremser, Leopold"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Med Univ Innsbruck, Clin Dept Nucl Med, A-6020 Innsbruck, Austria", 
      "name": "Decristoforo, Clemens"
    }
  ], 
  "datePublished": "2011-01-01", 
  "description": "Introduction: Lack of correlation between in vitro and in vivo stability is a general problem for the development of radiopeptides especially in the case of minigastrin derivatives for therapeutic applications. In this study, we compared the influence of experimental conditions on radiopeptide stability results in vitro using a model Minigastrin (MG) analogue labelled with Lu-177. Additionally, we attempted to characterize the main serum enzymatic cleavage sites by matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) analysis.", 
  "headline": "Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a Lu-177-DOTA-minigastrin derivative", 
  "identifier": 19493, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a Lu-177-DOTA-minigastrin derivative", 
  "url": "https://aperta.ulakbim.gov.tr/record/19493"
}