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Synthesis and asymmetric catalytic activity of (1S,1 ' S)-4,4 '-biquinazoline-based primary amines

Cakici, Murat; Catir, Mustafa; Karabuga, Semistan; Ulukanli, Sabri; Kilic, Hamdullah


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        "affiliation": "Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey", 
        "name": "Cakici, Murat"
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      {
        "name": "Catir, Mustafa"
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        "affiliation": "Kilis 7 Aralik Univ, Dept Chem, Fac Sci & Letters, Kilis, Turkey", 
        "name": "Karabuga, Semistan"
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      {
        "affiliation": "Osmaniye Korkut Ata Univ, Dept Chem, Fac Sci & Letters, Osmaniye, Turkey", 
        "name": "Ulukanli, Sabri"
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      {
        "affiliation": "Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey", 
        "name": "Kilic, Hamdullah"
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    "description": "A series of (1S,1'S)-4,4'-biquinazoline-based primary amines were prepared from natural amino acids via a six-step reaction sequence of protection and condensation followed by key synthetic steps including chlorination, nickel(0)-mediated homocoupling, and deprotection. These novel amines were screened for the asymmetric ethylation of aryl aldehydes to yield alcohols with an (S)-configuration with enantiomeric excesses (ee) varying from 2% to 95%. (C) 2011 Elsevier Ltd. All rights reserved.", 
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      "pages": "300-308", 
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