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Synthesis and asymmetric catalytic activity of (1S,1 ' S)-4,4 '-biquinazoline-based primary amines

Cakici, Murat; Catir, Mustafa; Karabuga, Semistan; Ulukanli, Sabri; Kilic, Hamdullah


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{
  "DOI": "10.1016/j.tetasy.2011.01.009", 
  "abstract": "A series of (1S,1'S)-4,4'-biquinazoline-based primary amines were prepared from natural amino acids via a six-step reaction sequence of protection and condensation followed by key synthetic steps including chlorination, nickel(0)-mediated homocoupling, and deprotection. These novel amines were screened for the asymmetric ethylation of aryl aldehydes to yield alcohols with an (S)-configuration with enantiomeric excesses (ee) varying from 2% to 95%. (C) 2011 Elsevier Ltd. All rights reserved.", 
  "author": [
    {
      "family": "Cakici", 
      "given": " Murat"
    }, 
    {
      "family": "Catir", 
      "given": " Mustafa"
    }, 
    {
      "family": "Karabuga", 
      "given": " Semistan"
    }, 
    {
      "family": "Ulukanli", 
      "given": " Sabri"
    }, 
    {
      "family": "Kilic", 
      "given": " Hamdullah"
    }
  ], 
  "container_title": "TETRAHEDRON-ASYMMETRY", 
  "id": "18135", 
  "issue": "3", 
  "issued": {
    "date-parts": [
      [
        2011, 
        1, 
        1
      ]
    ]
  }, 
  "page": "300-308", 
  "title": "Synthesis and asymmetric catalytic activity of (1S,1 ' S)-4,4 '-biquinazoline-based primary amines", 
  "type": "article-journal", 
  "volume": "22"
}
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