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The role of heat stress on the age related protein carbonylation

Bozaykut, Perinur; Sozen, Erdi; Kaga, Elif; Ece, Asli; Ozaltin, Esra; Ek, Bo; Ozer, Nesrin Kartal; Grune, Tilman; Bergquist, Jonas; Karademir, Betul


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/15875</identifier>
  <creators>
    <creator>
      <creatorName>Bozaykut, Perinur</creatorName>
      <givenName>Perinur</givenName>
      <familyName>Bozaykut</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sozen, Erdi</creatorName>
      <givenName>Erdi</givenName>
      <familyName>Sozen</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaga, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Kaga</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ece, Asli</creatorName>
      <givenName>Asli</givenName>
      <familyName>Ece</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozaltin, Esra</creatorName>
      <givenName>Esra</givenName>
      <familyName>Ozaltin</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ek, Bo</creatorName>
      <givenName>Bo</givenName>
      <familyName>Ek</familyName>
      <affiliation>Uppsala Univ, Dept Chem, BMC &amp; Sci Life Lab, SE-75124 Uppsala, Sweden</affiliation>
    </creator>
    <creator>
      <creatorName>Ozer, Nesrin Kartal</creatorName>
      <givenName>Nesrin Kartal</givenName>
      <familyName>Ozer</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Grune, Tilman</creatorName>
      <givenName>Tilman</givenName>
      <familyName>Grune</familyName>
      <affiliation>Univ Jena, Dept Nutr Toxicol, Inst Nutr, D-07743 Jena, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Bergquist, Jonas</creatorName>
      <givenName>Jonas</givenName>
      <familyName>Bergquist</familyName>
      <affiliation>Uppsala Univ, Dept Chem, BMC &amp; Sci Life Lab, SE-75124 Uppsala, Sweden</affiliation>
    </creator>
    <creator>
      <creatorName>Karademir, Betul</creatorName>
      <givenName>Betul</givenName>
      <familyName>Karademir</familyName>
      <affiliation>Marmara Univ, Dept Biochem, Fac Med, Genet &amp; Metab Dis Res &amp; Invest Ctr, TR-34668 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Role Of Heat Stress On The Age Related Protein Carbonylation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/15875</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jprot.2013.06.025</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Since the proteins are involved in many physiological processes in the organisms, modifications of proteins have important outcomes. Protein modifications are classified in several ways and oxidative stress related ones take a wide place. Aging is characterized by the accumulation of oxidized proteins and decreased degradation of these proteins. On the other hand protein turnover is an important regulatory mechanism for the control of protein homeostasis. Heat shock proteins are a highly conserved family of proteins in the various cells and organisms whose expressions are highly inducible during stress conditions. These proteins participate in protein assembly, trafficking, degradation and therefore play important role in protein turnover. Although the entire functions of each heat shock protein are still not completely investigated, these proteins have been implicated in the processes of protection and repair of stress-induced protein damage. This study has focused on the heat stress related carbonylated proteins, as a marker of oxidative protein modification, in young and senescent fibroblasts. The results are discussed with reference to potential involvement of induced heat shock proteins. This article is part of a Special Issue entitled: Protein Modifications.</description>
  </descriptions>
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