1 Ocak 2013 Dergi makalesi Açık Erişim

Bozaykut, Perinur; Sozen, Erdi; Kaga, Elif; Ece, Asli; Ozaltin, Esra; Ek, Bo; Ozer, Nesrin Kartal; Grune, Tilman; Bergquist, Jonas; Karademir, Betul

Citation Style Language JSON

{
  "DOI": "10.1016/j.jprot.2013.06.025", 
  "abstract": "Since the proteins are involved in many physiological processes in the organisms, modifications of proteins have important outcomes. Protein modifications are classified in several ways and oxidative stress related ones take a wide place. Aging is characterized by the accumulation of oxidized proteins and decreased degradation of these proteins. On the other hand protein turnover is an important regulatory mechanism for the control of protein homeostasis. Heat shock proteins are a highly conserved family of proteins in the various cells and organisms whose expressions are highly inducible during stress conditions. These proteins participate in protein assembly, trafficking, degradation and therefore play important role in protein turnover. Although the entire functions of each heat shock protein are still not completely investigated, these proteins have been implicated in the processes of protection and repair of stress-induced protein damage. This study has focused on the heat stress related carbonylated proteins, as a marker of oxidative protein modification, in young and senescent fibroblasts. The results are discussed with reference to potential involvement of induced heat shock proteins. This article is part of a Special Issue entitled: Protein Modifications.", 
  "author": [
    {
      "family": "Bozaykut", 
      "given": " Perinur"
    }, 
    {
      "family": "Sozen", 
      "given": " Erdi"
    }, 
    {
      "family": "Kaga", 
      "given": " Elif"
    }, 
    {
      "family": "Ece", 
      "given": " Asli"
    }, 
    {
      "family": "Ozaltin", 
      "given": " Esra"
    }, 
    {
      "family": "Ek", 
      "given": " Bo"
    }, 
    {
      "family": "Ozer", 
      "given": " Nesrin Kartal"
    }, 
    {
      "family": "Grune", 
      "given": " Tilman"
    }, 
    {
      "family": "Bergquist", 
      "given": " Jonas"
    }, 
    {
      "family": "Karademir", 
      "given": " Betul"
    }
  ], 
  "container_title": "JOURNAL OF PROTEOMICS", 
  "id": "15875", 
  "issued": {
    "date-parts": [
      [
        2013, 
        1, 
        1
      ]
    ]
  }, 
  "page": "238-254", 
  "title": "The role of heat stress on the age related protein carbonylation", 
  "type": "article-journal", 
  "volume": "89"
}