1 Ocak 2013 Dergi makalesi Açık Erişim

Ozcan, Ipek; Azizoglu, Erkan; Senyigit, Taner; Ozyazici, Mine; Ozer, Ozgen

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{
  "@context": "https://schema.org/", 
  "@id": 11931, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey", 
      "name": "Ozcan, Ipek"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey", 
      "name": "Azizoglu, Erkan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey", 
      "name": "Senyigit, Taner"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey", 
      "name": "Ozyazici, Mine"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey", 
      "name": "Ozer, Ozgen"
    }
  ], 
  "datePublished": "2013-01-01", 
  "description": "The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DFV was achieved without any initial burst release. Nanoparticles were also incorporated into chitosan gel at different ratios for preparing a more suitable formulation for topical drug delivery with adequate viscosity. In ex-vivo permeation studies, nanoparticles increased the accumulation of DFV especially in the stratum corneum + epidermis of rat skin without any significant permeation. Retention of DFV from nanoparticle in chitosan gel formulation (0.01%) was twofold higher than commercial cream, although it contained ten times less DFV. Nanoparticles in gel formulations produced significantly higher edema inhibition in rats compared with commercial cream in in-vivo studies. Skin blanching assay using a chromameter showed vasoconstriction similar to that of the commercial product. There were no barrier function changes upon application of nanoparticles. In-vitro and in-vivo results demonstrated that lecithin/chitosan nanoparticles in chitosan gel may be a promising carrier for dermal delivery of DFV in various skin disorders.", 
  "headline": "Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations", 
  "identifier": 11931, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations", 
  "url": "https://aperta.ulakbim.gov.tr/record/11931"
}