1 Ocak 2013 Dergi makalesi Açık Erişim

Ozcan, Ipek; Azizoglu, Erkan; Senyigit, Taner; Ozyazici, Mine; Ozer, Ozgen

Citation Style Language JSON

{
  "DOI": "10.2147/IJN.S40519", 
  "abstract": "The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DFV was achieved without any initial burst release. Nanoparticles were also incorporated into chitosan gel at different ratios for preparing a more suitable formulation for topical drug delivery with adequate viscosity. In ex-vivo permeation studies, nanoparticles increased the accumulation of DFV especially in the stratum corneum + epidermis of rat skin without any significant permeation. Retention of DFV from nanoparticle in chitosan gel formulation (0.01%) was twofold higher than commercial cream, although it contained ten times less DFV. Nanoparticles in gel formulations produced significantly higher edema inhibition in rats compared with commercial cream in in-vivo studies. Skin blanching assay using a chromameter showed vasoconstriction similar to that of the commercial product. There were no barrier function changes upon application of nanoparticles. In-vitro and in-vivo results demonstrated that lecithin/chitosan nanoparticles in chitosan gel may be a promising carrier for dermal delivery of DFV in various skin disorders.", 
  "author": [
    {
      "family": "Ozcan", 
      "given": " Ipek"
    }, 
    {
      "family": "Azizoglu", 
      "given": " Erkan"
    }, 
    {
      "family": "Senyigit", 
      "given": " Taner"
    }, 
    {
      "family": "Ozyazici", 
      "given": " Mine"
    }, 
    {
      "family": "Ozer", 
      "given": " Ozgen"
    }
  ], 
  "container_title": "INTERNATIONAL JOURNAL OF NANOMEDICINE", 
  "id": "11931", 
  "issued": {
    "date-parts": [
      [
        2013, 
        1, 
        1
      ]
    ]
  }, 
  "page": "461-475", 
  "title": "Enhanced dermal delivery of diflucortolone valerate using lecithin/chitosan nanoparticles: in-vitro and in-vivo evaluations", 
  "type": "article-journal", 
  "volume": "8"
}