1 Ocak 2013 Dergi makalesi Açık Erişim

Ozcan, Ipek; Azizoglu, Erkan; Senyigit, Taner; Ozyazici, Mine; Ozer, Ozgen

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/11931</identifier>
  <creators>
    <creator>
      <creatorName>Ozcan, Ipek</creatorName>
      <givenName>Ipek</givenName>
      <familyName>Ozcan</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Azizoglu, Erkan</creatorName>
      <givenName>Erkan</givenName>
      <familyName>Azizoglu</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Senyigit, Taner</creatorName>
      <givenName>Taner</givenName>
      <familyName>Senyigit</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozyazici, Mine</creatorName>
      <givenName>Mine</givenName>
      <familyName>Ozyazici</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozer, Ozgen</creatorName>
      <givenName>Ozgen</givenName>
      <familyName>Ozer</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Enhanced Dermal Delivery Of Diflucortolone Valerate Using Lecithin/Chitosan Nanoparticles: In-Vitro And In-Vivo Evaluations</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2013</publicationYear>
  <dates>
    <date dateType="Issued">2013-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/11931</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2147/IJN.S40519</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The objective of this study was to prepare a suitable formulation for dermal delivery of diflucortolone valerate (DFV) that would maintain the localization in skin layers without any penetration and to optimize efficiency of DFV. Drug-loaded lecithin/chitosan nanoparticles with high entrapment efficiency (86.8%), were successfully prepared by ionic interaction technique. Sustained release of DFV was achieved without any initial burst release. Nanoparticles were also incorporated into chitosan gel at different ratios for preparing a more suitable formulation for topical drug delivery with adequate viscosity. In ex-vivo permeation studies, nanoparticles increased the accumulation of DFV especially in the stratum corneum + epidermis of rat skin without any significant permeation. Retention of DFV from nanoparticle in chitosan gel formulation (0.01%) was twofold higher than commercial cream, although it contained ten times less DFV. Nanoparticles in gel formulations produced significantly higher edema inhibition in rats compared with commercial cream in in-vivo studies. Skin blanching assay using a chromameter showed vasoconstriction similar to that of the commercial product. There were no barrier function changes upon application of nanoparticles. In-vitro and in-vivo results demonstrated that lecithin/chitosan nanoparticles in chitosan gel may be a promising carrier for dermal delivery of DFV in various skin disorders.</description>
  </descriptions>
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