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Synthesis of Novel Benzothiophene Derivatives via Cyclization Reactions

Hama, A. K.; Algso, M. A. S.; Kavak, E.; Kivrak, A.


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/10523</identifier>
  <creators>
    <creator>
      <creatorName>Hama, A. K.</creatorName>
      <givenName>A. K.</givenName>
      <familyName>Hama</familyName>
      <affiliation>Van Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Algso, M. A. S.</creatorName>
      <givenName>M. A. S.</givenName>
      <familyName>Algso</familyName>
      <affiliation>Van Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kavak, E.</creatorName>
      <givenName>E.</givenName>
      <familyName>Kavak</familyName>
      <affiliation>Van Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kivrak, A.</creatorName>
      <givenName>A.</givenName>
      <familyName>Kivrak</familyName>
      <affiliation>Van Yuzuncu Yil Univ, Dept Chem, TR-65080 Van, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of Novel Benzothiophene Derivatives Via Cyclization Reactions</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/10523</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1134/S1070428020070222</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.</description>
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