1 Ocak 2020 Dergi makalesi Açık Erişim

Ilhan, Gulnihal Tok; Irmak, Gulseren; Gumusderelioglu, Menemse

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  <dc:creator>Ilhan, Gulnihal Tok</dc:creator>
  <dc:creator>Irmak, Gulseren</dc:creator>
  <dc:creator>Gumusderelioglu, Menemse</dc:creator>
  <dc:date>2020-01-01</dc:date>
  <dc:description>In this study, we aimed to obtain stable Kappa carrageenan (kappa Car) hydrogel that could be used as a bioink for cartilage regeneration. For this purpose, we described an effective and considerably faster methacrylation process by using microwave energy. Thus, microwave-methacrylated kappa Car (Mw-kappa Car-MA) with &gt;= 85% degree of methacrylation (DM) was synthesized despite the use of a low concentration of methacrylic anhydride (MA) at 1000 W in 5 min. Then, Mw-kappa Car-MA was photo-crosslinked by only using UV irradiation for 40 s. Characterization studies proved that Mw-kappa Car-MA hydrogels were stronger and have lower weight loss (similar to 20% at 30 days) than that of conventionally synthesized kappa Car-MA hydrogels. Viscosities of the Mw-kappa Car-MA hydrogels were found to be sufficient to use in 3D bioprinters. Furthermore, Mw-kappa Car-MA hydrogels enhanced the viability, proliferation, and GAG deposition of ATDC5 chondrogenic cells. Therefore, we proposed that Mw-kappa Car-MA can be considered as a suitable bioink for cartilage tissue engineering. (C) 2020 Published by Elsevier B.V.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/10261</dc:identifier>
  <dc:identifier>oai:zenodo.org:10261</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164 3523-3534</dc:source>
  <dc:title>Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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