1 Ocak 2020 Dergi makalesi Açık Erişim

Ilhan, Gulnihal Tok; Irmak, Gulseren; Gumusderelioglu, Menemse

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{
  "@context": "https://schema.org/", 
  "@id": 10261, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Bioengn Dept, TR-06800 Ankara, Turkey", 
      "name": "Ilhan, Gulnihal Tok"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Bioengn Dept, TR-06800 Ankara, Turkey", 
      "name": "Irmak, Gulseren"
    }, 
    {
      "@type": "Person", 
      "name": "Gumusderelioglu, Menemse"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "In this study, we aimed to obtain stable Kappa carrageenan (kappa Car) hydrogel that could be used as a bioink for cartilage regeneration. For this purpose, we described an effective and considerably faster methacrylation process by using microwave energy. Thus, microwave-methacrylated kappa Car (Mw-kappa Car-MA) with >= 85% degree of methacrylation (DM) was synthesized despite the use of a low concentration of methacrylic anhydride (MA) at 1000 W in 5 min. Then, Mw-kappa Car-MA was photo-crosslinked by only using UV irradiation for 40 s. Characterization studies proved that Mw-kappa Car-MA hydrogels were stronger and have lower weight loss (similar to 20% at 30 days) than that of conventionally synthesized kappa Car-MA hydrogels. Viscosities of the Mw-kappa Car-MA hydrogels were found to be sufficient to use in 3D bioprinters. Furthermore, Mw-kappa Car-MA hydrogels enhanced the viability, proliferation, and GAG deposition of ATDC5 chondrogenic cells. Therefore, we proposed that Mw-kappa Car-MA can be considered as a suitable bioink for cartilage tissue engineering. (C) 2020 Published by Elsevier B.V.", 
  "headline": "Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering", 
  "identifier": 10261, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Microwave assisted methacrylation of Kappa carrageenan: A bioink for cartilage tissue engineering", 
  "url": "https://aperta.ulakbim.gov.tr/record/10261"
}