1 Ocak 2020 Dergi makalesi Açık Erişim

Ilhan, Gulnihal Tok; Irmak, Gulseren; Gumusderelioglu, Menemse

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/10261</identifier>
  <creators>
    <creator>
      <creatorName>Ilhan, Gulnihal Tok</creatorName>
      <givenName>Gulnihal Tok</givenName>
      <familyName>Ilhan</familyName>
      <affiliation>Hacettepe Univ, Bioengn Dept, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Irmak, Gulseren</creatorName>
      <givenName>Gulseren</givenName>
      <familyName>Irmak</familyName>
      <affiliation>Hacettepe Univ, Bioengn Dept, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gumusderelioglu, Menemse</creatorName>
      <givenName>Menemse</givenName>
      <familyName>Gumusderelioglu</familyName>
    </creator>
  </creators>
  <titles>
    <title>Microwave Assisted Methacrylation Of Kappa Carrageenan: A Bioink For Cartilage Tissue Engineering</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/10261</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ijbiomac.2020.08.241</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
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  <descriptions>
    <description descriptionType="Abstract">In this study, we aimed to obtain stable Kappa carrageenan (kappa Car) hydrogel that could be used as a bioink for cartilage regeneration. For this purpose, we described an effective and considerably faster methacrylation process by using microwave energy. Thus, microwave-methacrylated kappa Car (Mw-kappa Car-MA) with &amp;gt;= 85% degree of methacrylation (DM) was synthesized despite the use of a low concentration of methacrylic anhydride (MA) at 1000 W in 5 min. Then, Mw-kappa Car-MA was photo-crosslinked by only using UV irradiation for 40 s. Characterization studies proved that Mw-kappa Car-MA hydrogels were stronger and have lower weight loss (similar to 20% at 30 days) than that of conventionally synthesized kappa Car-MA hydrogels. Viscosities of the Mw-kappa Car-MA hydrogels were found to be sufficient to use in 3D bioprinters. Furthermore, Mw-kappa Car-MA hydrogels enhanced the viability, proliferation, and GAG deposition of ATDC5 chondrogenic cells. Therefore, we proposed that Mw-kappa Car-MA can be considered as a suitable bioink for cartilage tissue engineering. (C) 2020 Published by Elsevier B.V.</description>
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