1 Ocak 2020 Dergi makalesi Açık Erişim

Gokce, Zeliha Guler; Birol, Semra Zuhal; Mitina, Nataliya; Harhay, Khrystyna; Finiuk, Nataliya; Glasunova, Valentina; Stoika, Rostyslav; Ercelen, Sebnem; Zaichenko, Alexander

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/89217</identifier>
  <creators>
    <creator>
      <creatorName>Gokce, Zeliha Guler</creatorName>
      <givenName>Zeliha Guler</givenName>
      <familyName>Gokce</familyName>
    </creator>
    <creator>
      <creatorName>Birol, Semra Zuhal</creatorName>
      <givenName>Semra Zuhal</givenName>
      <familyName>Birol</familyName>
    </creator>
    <creator>
      <creatorName>Mitina, Nataliya</creatorName>
      <givenName>Nataliya</givenName>
      <familyName>Mitina</familyName>
      <affiliation>Lviv Polytech Natl Univ, Dept Organ Chem, S Bandery 12, UA-79013 Lvov, Ukraine</affiliation>
    </creator>
    <creator>
      <creatorName>Harhay, Khrystyna</creatorName>
      <givenName>Khrystyna</givenName>
      <familyName>Harhay</familyName>
      <affiliation>Lviv Polytech Natl Univ, Dept Organ Chem, S Bandery 12, UA-79013 Lvov, Ukraine</affiliation>
    </creator>
    <creator>
      <creatorName>Finiuk, Nataliya</creatorName>
      <givenName>Nataliya</givenName>
      <familyName>Finiuk</familyName>
      <affiliation>Natl Acad Sci Ukraine, Inst Cell Biol, Dept Regulat Cell Proliferat, Lvov, Ukraine</affiliation>
    </creator>
    <creator>
      <creatorName>Glasunova, Valentina</creatorName>
      <givenName>Valentina</givenName>
      <familyName>Glasunova</familyName>
      <affiliation>Natl Acad Sci Ukraine, Donetsk OO Galkin Inst Phys &amp; Engn, Dept Phys Mat, Donetsk, Ukraine</affiliation>
    </creator>
    <creator>
      <creatorName>Stoika, Rostyslav</creatorName>
      <givenName>Rostyslav</givenName>
      <familyName>Stoika</familyName>
      <affiliation>Natl Acad Sci Ukraine, Inst Cell Biol, Dept Regulat Cell Proliferat, Lvov, Ukraine</affiliation>
    </creator>
    <creator>
      <creatorName>Ercelen, Sebnem</creatorName>
      <givenName>Sebnem</givenName>
      <familyName>Ercelen</familyName>
    </creator>
    <creator>
      <creatorName>Zaichenko, Alexander</creatorName>
      <givenName>Alexander</givenName>
      <familyName>Zaichenko</familyName>
      <affiliation>Lviv Polytech Natl Univ, Dept Organ Chem, S Bandery 12, UA-79013 Lvov, Ukraine</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Novel Amphiphilic Block-Copolymer Forming Stable Micelles And Interpolyelectrolyte Complexes With Dna For Efficient Gene Delivery</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/89217</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/00914037.2020.1740988</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Novel amphiphilic poly(DMAEMA)-block-poly(NVP-co-BA-co-AEM) (BP83-1) forms stable micelles and BP83-1/pDNA complexes possessing controlled size, charge and enhanced aggregation degree. It was found that the formation of the micelles by BP83-1 is necessary for successful DNA binding and compaction. The polyamphiphile micelle aggregation degree defined their crucial effect on the compaction and morphology of polyplexes. Strong compaction of the DNA upon interaction with polymer at CMC value, positive charge, and high stability of the polyplex are key factors promoting the penetration of DNA through bio-surfaces that define the efficiency of gene delivery in mammalian cells.</description>
  </descriptions>
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