1 Ocak 2012 Dergi makalesi Açık Erişim

Kallempudi, Sreenivasa Saravan; Altintas, Zeynep; Niazi, Javed H.; Gurbuz, Yasar

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  "@id": 86701, 
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  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey", 
      "name": "Kallempudi, Sreenivasa Saravan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey", 
      "name": "Altintas, Zeynep"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Sabanci Univ, Nanotechnol Res & Applicat Ctr, TR-34956 Istanbul, Turkey", 
      "name": "Niazi, Javed H."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey", 
      "name": "Gurbuz, Yasar"
    }
  ], 
  "datePublished": "2012-01-01", 
  "description": "This paper presents the realization of a portable, point-of-care and multi-target immunosensing lab-on-a-chip (LOC). The chip utilizes a novel on-chip actuating mechanism which uses a negative pressure to create thrust inside the channels to facilitate and control the fluid flow. No external instruments and/or sources were used to drive or control the liquid throughout the experimentation. LOC demonstrates a highly sensitive detection and quantification of a cancer marker, human-epidermal growth factor receptor (hEGFR) and a cardiac marker, interleukin 6 (IL-6) by impedimetric measurement approach. Without the use of any signal amplification methods (chemical), a dynamic detection limit of 3-8 ng/ml of hEGFR and 0.1-5 ng/ml of IL-6 in human serum was obtained. The extracted dissociation constants were calculated as 5.86 ng/ml (hEGFR) and 2.45 ng/ml (IL-6) by kinetic analysis. (C) 2012 Elsevier B.V. All rights reserved.", 
  "headline": "A new microfluidics system with a hand-operated, on-chip actuator for immunosensor applications", 
  "identifier": 86701, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "A new microfluidics system with a hand-operated, on-chip actuator for immunosensor applications", 
  "url": "https://aperta.ulakbim.gov.tr/record/86701"
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