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Intramolecular Heterocyclization of O-Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal-Free Conditions

Keskin, Selbi; Balci, Metin


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{
  "DOI": "10.1021/acs.orglett.5b00067", 
  "abstract": "A concise and regioselective approach to the synthesis of chromenopyridine and chromenopyridinone derivatives was developed. The synthetic strategy relies on the O-propargylation of aromatic hydroxyaldehydes followed by reaction with propargylamine. The intramolecular cycloaddition reaction between the alkyne and azadiene, which is formed as an intermediate, furnished the desired skeletons.", 
  "author": [
    {
      "family": "Keskin", 
      "given": " Selbi"
    }, 
    {
      "family": "Balci", 
      "given": " Metin"
    }
  ], 
  "container_title": "ORGANIC LETTERS", 
  "id": "79515", 
  "issue": "4", 
  "issued": {
    "date-parts": [
      [
        2015, 
        1, 
        1
      ]
    ]
  }, 
  "page": "964-967", 
  "title": "Intramolecular Heterocyclization of O-Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal-Free Conditions", 
  "type": "article-journal", 
  "volume": "17"
}
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