Dergi makalesi Açık Erişim
Baran, Alper; Sulukan, Ekrem; Turkoglu, Medine; Ghosigharehagaji, Atena; Yildirim, Serkan; Kankaynar, Meryem; Bolat, Ismail; Kaya, Mukerrem; Topal, Ahmet; Ceyhun, Saltuk Bugrahan
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES</subfield> <subfield code="v">163</subfield> <subfield code="c">2465-2473</subfield> </datafield> <controlfield tag="001">7433</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">The toxicity of sodiumcarboxymethyl cellulose (CMC), which has GRAS status and has been determined as "ADI non specified", was re-evaluated with a new modelling and molecular-based data. For this purpose, CMC, a food additive, was injected to the yolk sac (food) of the zebrafish embryo by the microinjection method at the 4th hour of fertilization at different concentrations. As a result, it was found that CMC showed no toxic effects within the framework of the parameters studied. But, we determined increasing lipid accumulation in zebrafish embryos exposed to CMC in a dose-dependent manner. To elucidate the mechanism underlying this lipid accumulation, the expression levels of genes related to obesity-linked lipid metabolism were examined. Our findings show that while CMC does not cause a toxic effect in zebrafish embryos, it can lead important effects on lipid metabolism by causing changes in the expression of some genes associated with obesity. (C) 2020 Elsevier B.V. All rights reserved.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Sulukan, Ekrem</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Turkoglu, Medine</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Fac Fisheries, Aquat Biotechnol Lab, Erzurum, Turkey</subfield> <subfield code="a">Ghosigharehagaji, Atena</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Fac Vet, Dept Pathol, Erzurum, Turkey</subfield> <subfield code="a">Yildirim, Serkan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kankaynar, Meryem</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Fac Vet, Dept Pathol, Erzurum, Turkey</subfield> <subfield code="a">Bolat, Ismail</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Fac Agr, Dept Food Engn, Erzurum, Turkey</subfield> <subfield code="a">Kaya, Mukerrem</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Fac Fisheries, Dept Basic Sci, TR-25240 Erzurum, Turkey</subfield> <subfield code="a">Topal, Ahmet</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Ceyhun, Saltuk Bugrahan</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Ataturk Univ, Erzurum Vocat Sch, Dept Food Qual & Anal, Erzurum, Turkey</subfield> <subfield code="a">Baran, Alper</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2020-01-01</subfield> </datafield> <controlfield tag="005">20210315063852.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:7433</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:837ef2bc0a01a0cceae05d64e87dafc3</subfield> <subfield code="s">312</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/7433/files/bib-0e80ba8f-78b9-434d-acd8-3d0d9ec29f0e.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.ijbiomac.2020.09.169</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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