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Cucurbit[7]uril-Anchored Porphyrin-Based Multifunctional Molecular Platform for Photodynamic Antimicrobial and Cancer Therapy

Ozkan, Melis; Kumar, Yogesh; Keser, Yagmur; Hadi, Seyed E.; Tuncel, Donus


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{
  "DOI": "10.1021/acsabm.9b00763", 
  "abstract": "Here we report a photoactive supramolecular assembly that is multifunctional and constructed by covalently linking four receptor molecules (cucurbit[7]uril) to a porphyrin derivative with suitable linkers. While this molecular platform serves very efficiently as a light-triggered broad-spectrum antibacterial agent, owing to its negligible dark cytotoxicity and the presence of host molecules (CB7), it can also be utilized as a vehicle to carry drug molecules for a combined chemo and photodynamic cancer therapy.", 
  "author": [
    {
      "family": "Ozkan", 
      "given": " Melis"
    }, 
    {
      "family": "Kumar", 
      "given": " Yogesh"
    }, 
    {
      "family": "Keser", 
      "given": " Yagmur"
    }, 
    {
      "family": "Hadi", 
      "given": " Seyed E."
    }, 
    {
      "family": "Tuncel", 
      "given": " Donus"
    }
  ], 
  "container_title": "ACS APPLIED BIO MATERIALS", 
  "id": "72299", 
  "issue": "11", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "4693-4697", 
  "title": "Cucurbit[7]uril-Anchored Porphyrin-Based Multifunctional Molecular Platform for Photodynamic Antimicrobial and Cancer Therapy", 
  "type": "article-journal", 
  "volume": "2"
}
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