1 Ocak 2021 Dergi makalesi Açık Erişim

Akdal, Gulden; Kocoglu, Koray; Tanriverdizade, Tural; Bora, Elcin; Bademkiran, Fikret; Yuceyar, Ayse Nur; Ekmekci, Ozgul; Sengun, Ihsan Sukru; Karasoy, Hatice

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    <subfield code="u">Dokuz Eylul Univ, Fac Med, Dept Med Genet, Izmir, Turkey</subfield>
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    <subfield code="u">Ege Univ, Fac Med, Dept Neurol, Izmir, Turkey</subfield>
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    <subfield code="u">Ege Univ, Fac Med, Dept Neurol, Izmir, Turkey</subfield>
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    <subfield code="a">Sengun, Ihsan Sukru</subfield>
    <subfield code="u">Dokuz Eylul Univ, Fac Med, Dept Neurol, Izmir, Turkey</subfield>
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    <subfield code="u">Ege Univ, Fac Med, Dept Neurol, Izmir, Turkey</subfield>
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  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Vestibular impairment in Charcot-Marie-Tooth disease</subfield>
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    <subfield code="a">Akdal, Gulden</subfield>
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    <subfield code="a">Objective To find out if Charcot-Marie-Tooth (CMT) patients, who have peripheral vestibular as well as peripheral somatosensory impairment, have worse postural balance than those who do not. Methods We studied 32 patients with various CMT phenotypes and genotypes. Vestibular function was measured with the video head impulse test (vHIT) which tests vestibulo-ocular reflex (VOR) gain from each of the six semicircular canals in response to rapid head rotations. Postural balance was evaluated with a battery of four postural tests with emphasis on the modified clinical test of sensory integration in balance (mCTSIB). Results Half of the 32 patients had some impairment of vestibular function ranging from mild, affecting only 1-2 semicircular canals, to almost total affecting all 6 semicircular canals. Their mCTSIB scores correlated with VOR gain from the vertical rather than from the lateral semicircular canals. The worse the vertical VOR gain the worse the mCTSIB score. Conclusion We propose that any CMT patient could have clinically inapparent vestibular impairment that can be easily measured with the vHIT. This vestibular impairment could be contributing to their imbalance and could respond to a focused vestibular rehabilitation program.</subfield>
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