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One-Pot Synthesis of Spiro-2H-pyrroles fromN-Propargylic beta-Enaminones

Karadeniz, Eda; Zora, Metin


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{
  "DOI": "10.1055/s-0037-1611816", 
  "abstract": "A simple and general one-pot method for the synthesis of spiro-2 H -pyrroles has been developed. Initially, cyclohexane-embedded -enaminones with internal alkyne functionality were synthesized by conjugate addition of 1-ethynylcyclohexylamine to ,-alkynic ketones, followed by palladium-catalyzed coupling of the resulting N -propargylic -enaminones with aryl iodides. When subjected to basic conditions, the cyclohexane-embedded -enaminones with internal alkyne functionality underwent tandem nucleophilic cyclization and benzylic C-H oxidation to furnish 3,4-diaryloyl-1-azaspiro[4.5]deca-1,3-diene derivatives in good yields.", 
  "author": [
    {
      "family": "Karadeniz", 
      "given": " Eda"
    }, 
    {
      "family": "Zora", 
      "given": " Metin"
    }
  ], 
  "container_title": "SYNLETT", 
  "id": "70551", 
  "issue": "10", 
  "issued": {
    "date-parts": [
      [
        2019, 
        1, 
        1
      ]
    ]
  }, 
  "page": "1231-1236", 
  "title": "One-Pot Synthesis of Spiro-2H-pyrroles fromN-Propargylic beta-Enaminones", 
  "type": "article-journal", 
  "volume": "30"
}
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Karadeniz, E. ve Zora, M. (2019). One-Pot Synthesis of Spiro-2H-pyrroles fromN-Propargylic beta-Enaminones. SYNLETT, 30(10), 1231–1236. doi:10.1055/s-0037-1611816

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