1 Ocak 2019 Dergi makalesi Açık Erişim

Kocaoglu, Esma; Talaz, Oktay; Cavdar, Huseyin; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:zenodo.org:69885</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8 m, 8 n, and 8 q, were determined to be the most powerful among them. Findings of our study indicates that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalarial candidates.</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Kocaoglu, Esma</subfield>
    <subfield code="u">Karamanoglu Mehmet Bey Univ, Kamil Ozdag Sci Fac, TR-70100 Karaman, Turkey</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:86a1b85834728b4ea82837598b0d2d7d</subfield>
    <subfield code="s">254</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/69885/files/bib-f4275619-7ca6-49e8-8e56-ed48b0ea4d33.txt</subfield>
  </datafield>
  <controlfield tag="005">20210316030805.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2019-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1080/14756366.2018.1520228</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">34</subfield>
    <subfield code="p">JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY</subfield>
    <subfield code="c">51-54</subfield>
    <subfield code="n">1</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Talaz, Oktay</subfield>
    <subfield code="u">Karamanoglu Mehmet Bey Univ, Kamil Ozdag Sci Fac, TR-70100 Karaman, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Cavdar, Huseyin</subfield>
    <subfield code="u">Dumlupinar Univ, Educ Fac, Kutahya, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Senturk, Murat</subfield>
    <subfield code="u">Ibrahim Cecen Univ Agri, Pharm Fac, Agri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Supuran, Claudiu T.</subfield>
    <subfield code="u">Univ Florence, Neurofarba Dept, Florence, Italy</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ekinci, Deniz</subfield>
    <subfield code="u">Ondokuz Mayis Univ, Dept Agr Biotechnol, Fac Agr, Samsun, Turkey</subfield>
  </datafield>
  <controlfield tag="001">69885</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>