1 Ocak 2019 Dergi makalesi Açık Erişim

Kocaoglu, Esma; Talaz, Oktay; Cavdar, Huseyin; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/69885</identifier>
  <creators>
    <creator>
      <creatorName>Kocaoglu, Esma</creatorName>
      <givenName>Esma</givenName>
      <familyName>Kocaoglu</familyName>
      <affiliation>Karamanoglu Mehmet Bey Univ, Kamil Ozdag Sci Fac, TR-70100 Karaman, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Talaz, Oktay</creatorName>
      <givenName>Oktay</givenName>
      <familyName>Talaz</familyName>
      <affiliation>Karamanoglu Mehmet Bey Univ, Kamil Ozdag Sci Fac, TR-70100 Karaman, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cavdar, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Cavdar</familyName>
      <affiliation>Dumlupinar Univ, Educ Fac, Kutahya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Senturk, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Senturk</familyName>
      <affiliation>Ibrahim Cecen Univ Agri, Pharm Fac, Agri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Supuran, Claudiu T.</creatorName>
      <givenName>Claudiu T.</givenName>
      <familyName>Supuran</familyName>
      <affiliation>Univ Florence, Neurofarba Dept, Florence, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Ekinci, Deniz</creatorName>
      <givenName>Deniz</givenName>
      <familyName>Ekinci</familyName>
      <affiliation>Ondokuz Mayis Univ, Dept Agr Biotechnol, Fac Agr, Samsun, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Determination Of The Inhibitory Effects Of N-Methylpyrrole Derivatives On Glutathione Reductase Enzyme</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/69885</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/14756366.2018.1520228</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, thus inhibitors of this enzyme are expected to be promising candidates for the treatment of malaria. In this work, GR inhibitory properties of N-Methylpyrrole derivatives are reported. It was found that all compounds have better inhibitory activity than the strong GR inhibitor N,N-bis(2-chloroethyl)-N-nitrosourea, especially three molecules, 8 m, 8 n, and 8 q, were determined to be the most powerful among them. Findings of our study indicates that these Schiff base derivatives are strong GR inhibitors which can be used as leads for designation of novel antimalarial candidates.</description>
  </descriptions>
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