1 Ocak 2014 Dergi makalesi Açık Erişim

Citak-Er, Fusun; Vural, Metin; Acar, Omer; Esen, Tarik; Onay, Aslihan; Ozturk-Isik, Esin

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  <dc:creator>Citak-Er, Fusun</dc:creator>
  <dc:creator>Vural, Metin</dc:creator>
  <dc:creator>Acar, Omer</dc:creator>
  <dc:creator>Esen, Tarik</dc:creator>
  <dc:creator>Onay, Aslihan</dc:creator>
  <dc:creator>Ozturk-Isik, Esin</dc:creator>
  <dc:date>2014-01-01</dc:date>
  <dc:description>Objective. This study aimed at evaluating linear discriminant analysis (LDA) and support vector machine (SVM) classifiers for estimating final Gleason score preoperatively using multiparametric magnetic resonance imaging (mp-MRI) and clinical parameters. Materials and Methods. Thirty-three patients who underwent mp-MRI on a 3T clinical MR scanner and radical prostatectomy were enrolled in this study. The input features for classifiers were age, the presence of a palpable prostate abnormality, prostate specific antigen (PSA) level, index lesion size, and Likert scales of T2 weighted MRI (T2w-MRI), diffusion weighted MRI (DW-MRI), and dynamic contrast enhanced MRI (DCE-MRI) estimated by an experienced radiologist. SVM based recursive feature elimination (SVM-RFE) was used for eliminating features. Principal component analysis (PCA) was applied for data uncorrelation. Results. Using a standard PCA before final Gleason score classification resulted in mean sensitivities of 51.19% and 64.37% andmean specificities of 72.71% and 39.90% for LDA and SVM, respectively. Using a Gaussian kernel PCA resulted in mean sensitivities of 86.51% and 87.88% and mean specificities of 63.99% and 56.83% for LDA and SVM, respectively. Conclusion. SVM classifier resulted in a slightly higher sensitivity but a lower specificity than LDA method for final Gleason score prediction for prostate cancer for this limited patient population.</dc:description>
  <dc:identifier>https://aperta.ulakbim.gov.trrecord/64255</dc:identifier>
  <dc:identifier>oai:zenodo.org:64255</dc:identifier>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>http://www.opendefinition.org/licenses/cc-by</dc:rights>
  <dc:source>BIOMED RESEARCH INTERNATIONAL 2014</dc:source>
  <dc:title>Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
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