1 Ocak 2014 Dergi makalesi Açık Erişim

Citak-Er, Fusun; Vural, Metin; Acar, Omer; Esen, Tarik; Onay, Aslihan; Ozturk-Isik, Esin

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    "creators": [
      {
        "affiliation": "Yeditepe Univ, Dept Genet & Bioengn, TR-34755 Istanbul, Turkey", 
        "name": "Citak-Er, Fusun"
      }, 
      {
        "affiliation": "VKF Amer Hosp, Dept Radiol, TR-34365 Istanbul, Turkey", 
        "name": "Vural, Metin"
      }, 
      {
        "affiliation": "VKF Amer Hosp, Dept Urol, TR-34365 Istanbul, Turkey", 
        "name": "Acar, Omer"
      }, 
      {
        "name": "Esen, Tarik"
      }, 
      {
        "affiliation": "VKF Amer Hosp, Dept Radiol, TR-34365 Istanbul, Turkey", 
        "name": "Onay, Aslihan"
      }, 
      {
        "affiliation": "Bogazici Univ, Inst Biomed Engn, TR-34684 Istanbul, Turkey", 
        "name": "Ozturk-Isik, Esin"
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    "description": "Objective. This study aimed at evaluating linear discriminant analysis (LDA) and support vector machine (SVM) classifiers for estimating final Gleason score preoperatively using multiparametric magnetic resonance imaging (mp-MRI) and clinical parameters. Materials and Methods. Thirty-three patients who underwent mp-MRI on a 3T clinical MR scanner and radical prostatectomy were enrolled in this study. The input features for classifiers were age, the presence of a palpable prostate abnormality, prostate specific antigen (PSA) level, index lesion size, and Likert scales of T2 weighted MRI (T2w-MRI), diffusion weighted MRI (DW-MRI), and dynamic contrast enhanced MRI (DCE-MRI) estimated by an experienced radiologist. SVM based recursive feature elimination (SVM-RFE) was used for eliminating features. Principal component analysis (PCA) was applied for data uncorrelation. Results. Using a standard PCA before final Gleason score classification resulted in mean sensitivities of 51.19% and 64.37% andmean specificities of 72.71% and 39.90% for LDA and SVM, respectively. Using a Gaussian kernel PCA resulted in mean sensitivities of 86.51% and 87.88% and mean specificities of 63.99% and 56.83% for LDA and SVM, respectively. Conclusion. SVM classifier resulted in a slightly higher sensitivity but a lower specificity than LDA method for final Gleason score prediction for prostate cancer for this limited patient population.", 
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    "journal": {
      "title": "BIOMED RESEARCH INTERNATIONAL", 
      "volume": "2014"
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    "publication_date": "2014-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Final Gleason Score Prediction Using Discriminant Analysis and Support Vector Machine Based on Preoperative Multiparametric MR Imaging of Prostate Cancer at 3T"
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