1 Ocak 2014 Dergi makalesi Açık Erişim

Ulusoy, Canan; Kim, Eunmi; Tuzun, Erdem; Huda, Ruksana; Yilmaz, Vuslat; Poulas, Konstantinos; Trakas, Nikos; Skriapa, Lamprini; Niarchos, Athanasios; Strait, Richard T.; Finkelman, Fred D.; Turan, Selin; Zisimopoulou, Paraskevi; Tzartos, Socrates; Saruhan-Direskeneli, Guher; Christadoss, Premkumar

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    "creators": [
      {
        "affiliation": "Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey", 
        "name": "Ulusoy, Canan"
      }, 
      {
        "affiliation": "Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA", 
        "name": "Kim, Eunmi"
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      {
        "affiliation": "Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey", 
        "name": "Tuzun, Erdem"
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      {
        "affiliation": "Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA", 
        "name": "Huda, Ruksana"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34393 Istanbul, Turkey", 
        "name": "Yilmaz, Vuslat"
      }, 
      {
        "affiliation": "Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece", 
        "name": "Poulas, Konstantinos"
      }, 
      {
        "affiliation": "Hellenic Pasteur Inst, Athens 11521, Greece", 
        "name": "Trakas, Nikos"
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      {
        "name": "Skriapa, Lamprini"
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      {
        "affiliation": "Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece", 
        "name": "Niarchos, Athanasios"
      }, 
      {
        "name": "Strait, Richard T."
      }, 
      {
        "name": "Finkelman, Fred D."
      }, 
      {
        "affiliation": "Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey", 
        "name": "Turan, Selin"
      }, 
      {
        "affiliation": "Hellenic Pasteur Inst, Athens 11521, Greece", 
        "name": "Zisimopoulou, Paraskevi"
      }, 
      {
        "name": "Tzartos, Socrates"
      }, 
      {
        "affiliation": "Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34393 Istanbul, Turkey", 
        "name": "Saruhan-Direskeneli, Guher"
      }, 
      {
        "affiliation": "Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA", 
        "name": "Christadoss, Premkumar"
      }
    ], 
    "description": "Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific receptor kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4)-antibodies. MuSK-antibodies are predominantly of the non-complement fixing IgG4 isotype. The MuSK associated experimental autoimmune myasthenia gravis (EAMG) model was established in mice to investigate immunoglobulin (Ig) and cytokine responses related with MuSK immunity. C57BL/6 (B6) mice immunized with 30 mu g of recombinant human MuSK in incomplete or complete Freund's adjuvant (CFA) showed significant EAMG susceptibility (>80% incidence). Although mice immunized with 10 mu g of MuSK had lower EAMG incidence (14.3%), serum MuSK-antibody levels were comparable to mice immunized with 30 mu g MuSK. While MuSK immunization stimulated production of all antibody isotypes, non-complement fixing IgG1 was the dominant anti-MuSK Ig isotype in both sera and neuromuscular junctions. Moreover, MuSK immunized IgG1 knockout mice showed very low serum MuSK-antibody levels. Sera and MuSK-stimulated lymph node cell supernatants of MuSK immunized mice showed significantly higher levels of IL-4 and IL-10 (but not IFN-gamma and IL-12), than those of CFA immunized mice. Our results suggest that through activation of Th2-type cells, anti-MuSK immunity promotes production of IL-4, which in turn activates anti-MuSK IgG1, the mouse analog of human IgG4. These findings might provide clues for the pathogenesis of other IgG4-related diseases as well as development of disease specific treatment methods (e.g. specific IgG4 inhibitors) for MuSK-related MG. (c) 2014 Elsevier Inc. All rights reserved.", 
    "doi": "10.1016/j.clim.2014.02.012", 
    "has_grant": false, 
    "journal": {
      "issue": "2", 
      "pages": "155-163", 
      "title": "CLINICAL IMMUNOLOGY", 
      "volume": "151"
    }, 
    "license": {
      "id": "cc-by"
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    "publication_date": "2014-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice"
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