1 Ocak 2014 Dergi makalesi Açık Erişim

Ulusoy, Canan; Kim, Eunmi; Tuzun, Erdem; Huda, Ruksana; Yilmaz, Vuslat; Poulas, Konstantinos; Trakas, Nikos; Skriapa, Lamprini; Niarchos, Athanasios; Strait, Richard T.; Finkelman, Fred D.; Turan, Selin; Zisimopoulou, Paraskevi; Tzartos, Socrates; Saruhan-Direskeneli, Guher; Christadoss, Premkumar

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/63409</identifier>
  <creators>
    <creator>
      <creatorName>Ulusoy, Canan</creatorName>
      <givenName>Canan</givenName>
      <familyName>Ulusoy</familyName>
      <affiliation>Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kim, Eunmi</creatorName>
      <givenName>Eunmi</givenName>
      <familyName>Kim</familyName>
      <affiliation>Univ Texas Med Branch, Dept Microbiol &amp; Immunol, Galveston, TX 77555 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Tuzun, Erdem</creatorName>
      <givenName>Erdem</givenName>
      <familyName>Tuzun</familyName>
      <affiliation>Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Huda, Ruksana</creatorName>
      <givenName>Ruksana</givenName>
      <familyName>Huda</familyName>
      <affiliation>Univ Texas Med Branch, Dept Microbiol &amp; Immunol, Galveston, TX 77555 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Vuslat</creatorName>
      <givenName>Vuslat</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34393 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Poulas, Konstantinos</creatorName>
      <givenName>Konstantinos</givenName>
      <familyName>Poulas</familyName>
      <affiliation>Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Trakas, Nikos</creatorName>
      <givenName>Nikos</givenName>
      <familyName>Trakas</familyName>
      <affiliation>Hellenic Pasteur Inst, Athens 11521, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Skriapa, Lamprini</creatorName>
      <givenName>Lamprini</givenName>
      <familyName>Skriapa</familyName>
    </creator>
    <creator>
      <creatorName>Niarchos, Athanasios</creatorName>
      <givenName>Athanasios</givenName>
      <familyName>Niarchos</familyName>
      <affiliation>Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Strait, Richard T.</creatorName>
      <givenName>Richard T.</givenName>
      <familyName>Strait</familyName>
    </creator>
    <creator>
      <creatorName>Finkelman, Fred D.</creatorName>
      <givenName>Fred D.</givenName>
      <familyName>Finkelman</familyName>
    </creator>
    <creator>
      <creatorName>Turan, Selin</creatorName>
      <givenName>Selin</givenName>
      <familyName>Turan</familyName>
      <affiliation>Istanbul Univ, Dept Neurosci, Expt Med Res Inst, TR-34393 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zisimopoulou, Paraskevi</creatorName>
      <givenName>Paraskevi</givenName>
      <familyName>Zisimopoulou</familyName>
      <affiliation>Hellenic Pasteur Inst, Athens 11521, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Tzartos, Socrates</creatorName>
      <givenName>Socrates</givenName>
      <familyName>Tzartos</familyName>
    </creator>
    <creator>
      <creatorName>Saruhan-Direskeneli, Guher</creatorName>
      <givenName>Guher</givenName>
      <familyName>Saruhan-Direskeneli</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Physiol, TR-34393 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Christadoss, Premkumar</creatorName>
      <givenName>Premkumar</givenName>
      <familyName>Christadoss</familyName>
      <affiliation>Univ Texas Med Branch, Dept Microbiol &amp; Immunol, Galveston, TX 77555 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Preferential Production Of Igg1, Il-4 And Il-10 In Musk-Immunized Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2014</publicationYear>
  <dates>
    <date dateType="Issued">2014-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/63409</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.clim.2014.02.012</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific receptor kinase (MuSK) or low-density lipoprotein receptor-related protein 4 (LRP4)-antibodies. MuSK-antibodies are predominantly of the non-complement fixing IgG4 isotype. The MuSK associated experimental autoimmune myasthenia gravis (EAMG) model was established in mice to investigate immunoglobulin (Ig) and cytokine responses related with MuSK immunity. C57BL/6 (B6) mice immunized with 30 mu g of recombinant human MuSK in incomplete or complete Freund's adjuvant (CFA) showed significant EAMG susceptibility (&amp;gt;80% incidence). Although mice immunized with 10 mu g of MuSK had lower EAMG incidence (14.3%), serum MuSK-antibody levels were comparable to mice immunized with 30 mu g MuSK. While MuSK immunization stimulated production of all antibody isotypes, non-complement fixing IgG1 was the dominant anti-MuSK Ig isotype in both sera and neuromuscular junctions. Moreover, MuSK immunized IgG1 knockout mice showed very low serum MuSK-antibody levels. Sera and MuSK-stimulated lymph node cell supernatants of MuSK immunized mice showed significantly higher levels of IL-4 and IL-10 (but not IFN-gamma and IL-12), than those of CFA immunized mice. Our results suggest that through activation of Th2-type cells, anti-MuSK immunity promotes production of IL-4, which in turn activates anti-MuSK IgG1, the mouse analog of human IgG4. These findings might provide clues for the pathogenesis of other IgG4-related diseases as well as development of disease specific treatment methods (e.g. specific IgG4 inhibitors) for MuSK-related MG. (c) 2014 Elsevier Inc. All rights reserved.</description>
  </descriptions>
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