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Kiefer, Karin; Akpinar, Gurler; Haidar, Ayman; Ikier, Tuba; Akkan, Cagri Kaan; Akman, Erhan; Lee, Juseok; Miro, Marina Martinez; Kacar, Elif; Demir, Arif; Veith, Michael; Ural, Dilek; Kasap, Murat; Kesmez, Mehmet; Abdul-Khaliq, Hashim; Aktas, Cenk
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Al2O3 micro- and nanostructures affect vascular cell response</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">RSC ADVANCES</subfield> <subfield code="v">6</subfield> <subfield code="n">21</subfield> <subfield code="c">17460-17469</subfield> </datafield> <controlfield tag="001">56701</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">In-stent restenosis (ISR) is one of the most common and serious complications observed after stent implantation. ISR is characterized by the inordinate proliferation of smooth muscle cells (SMC) that leads to narrowing of the blood vessels. To achieve a healthy endothelium, it is critical to selectively enhance the growth of endothelial cells (EC) while suppressing the growth of smooth muscle cells, which is still a major challenge and yet to be achieved. In this study, novel surfaces have been developed to support the selective growth of endothelial cells. Micro-and nanostructured Al2O3 surfaces with unique topographical features were fabricated and tested. Surface characterization and cellular response of endothelial cells (HUVEC) as well as smooth muscle cells (HUVSMC) has been investigated at cellular and molecular levels. A topography driven selective cell response of ECs over SMCs was demonstrated successfully. This selective response of ECs was also analyzed at protein levels in order to understand the basic mechanism.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Sch Med, DEKART Prote Lab, TR-41380 Umuttepe, Kocaeli, Turkey</subfield> <subfield code="a">Akpinar, Gurler</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Saarland, Clin Paediat Cardiol, D-66421 Homburg, Germany</subfield> <subfield code="a">Haidar, Ayman</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Laser Technol Res & Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</subfield> <subfield code="a">Ikier, Tuba</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Akkan, Cagri Kaan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Laser Technol Res & Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</subfield> <subfield code="a">Akman, Erhan</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">INM Leibniz Inst New Mat, D-66123 Saarbrucken, Germany</subfield> <subfield code="a">Lee, Juseok</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">INM Leibniz Inst New Mat, D-66123 Saarbrucken, Germany</subfield> <subfield code="a">Miro, Marina Martinez</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Laser Technol Res & Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</subfield> <subfield code="a">Kacar, Elif</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Laser Technol Res & Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</subfield> <subfield code="a">Demir, Arif</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Saarland, Dept Inorgan Chem, D-66123 Saarbrucken, Germany</subfield> <subfield code="a">Veith, Michael</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Kocaeli Univ, Sch Med, Dept Cardiol, TR-41380 Umuttepe, Kocaeli, Turkey</subfield> <subfield code="a">Ural, Dilek</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kasap, Murat</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Meliksah Univ, Res & Dev Ctr, TR-38280 Kayseri, Turkey</subfield> <subfield code="a">Kesmez, Mehmet</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Univ Saarland, Clin Paediat Cardiol, D-66421 Homburg, Germany</subfield> <subfield code="a">Abdul-Khaliq, Hashim</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Aktas, Cenk</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Kiefer, Karin</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2016-01-01</subfield> </datafield> <controlfield tag="005">20210316000749.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:56701</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:c3a94e23f876b9b353849584a76c8a14</subfield> <subfield code="s">288</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/56701/files/bib-34c03639-af9e-45d2-83a3-f6a09b9803fb.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1039/c5ra21775j</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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