1 Ocak 2016 Dergi makalesi Açık Erişim

Kiefer, Karin; Akpinar, Gurler; Haidar, Ayman; Ikier, Tuba; Akkan, Cagri Kaan; Akman, Erhan; Lee, Juseok; Miro, Marina Martinez; Kacar, Elif; Demir, Arif; Veith, Michael; Ural, Dilek; Kasap, Murat; Kesmez, Mehmet; Abdul-Khaliq, Hashim; Aktas, Cenk

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/56701</identifier>
  <creators>
    <creator>
      <creatorName>Kiefer, Karin</creatorName>
      <givenName>Karin</givenName>
      <familyName>Kiefer</familyName>
    </creator>
    <creator>
      <creatorName>Akpinar, Gurler</creatorName>
      <givenName>Gurler</givenName>
      <familyName>Akpinar</familyName>
      <affiliation>Kocaeli Univ, Sch Med, DEKART Prote Lab, TR-41380 Umuttepe, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Haidar, Ayman</creatorName>
      <givenName>Ayman</givenName>
      <familyName>Haidar</familyName>
      <affiliation>Univ Saarland, Clin Paediat Cardiol, D-66421 Homburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Ikier, Tuba</creatorName>
      <givenName>Tuba</givenName>
      <familyName>Ikier</familyName>
      <affiliation>Kocaeli Univ, Laser Technol Res &amp; Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akkan, Cagri Kaan</creatorName>
      <givenName>Cagri Kaan</givenName>
      <familyName>Akkan</familyName>
    </creator>
    <creator>
      <creatorName>Akman, Erhan</creatorName>
      <givenName>Erhan</givenName>
      <familyName>Akman</familyName>
      <affiliation>Kocaeli Univ, Laser Technol Res &amp; Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Lee, Juseok</creatorName>
      <givenName>Juseok</givenName>
      <familyName>Lee</familyName>
      <affiliation>INM Leibniz Inst New Mat, D-66123 Saarbrucken, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Miro, Marina Martinez</creatorName>
      <givenName>Marina Martinez</givenName>
      <familyName>Miro</familyName>
      <affiliation>INM Leibniz Inst New Mat, D-66123 Saarbrucken, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Kacar, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Kacar</familyName>
      <affiliation>Kocaeli Univ, Laser Technol Res &amp; Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demir, Arif</creatorName>
      <givenName>Arif</givenName>
      <familyName>Demir</familyName>
      <affiliation>Kocaeli Univ, Laser Technol Res &amp; Applicat Ctr, TR-41380 Basiskele, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Veith, Michael</creatorName>
      <givenName>Michael</givenName>
      <familyName>Veith</familyName>
      <affiliation>Univ Saarland, Dept Inorgan Chem, D-66123 Saarbrucken, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Ural, Dilek</creatorName>
      <givenName>Dilek</givenName>
      <familyName>Ural</familyName>
      <affiliation>Kocaeli Univ, Sch Med, Dept Cardiol, TR-41380 Umuttepe, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kasap, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Kasap</familyName>
    </creator>
    <creator>
      <creatorName>Kesmez, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Kesmez</familyName>
      <affiliation>Meliksah Univ, Res &amp; Dev Ctr, TR-38280 Kayseri, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Abdul-Khaliq, Hashim</creatorName>
      <givenName>Hashim</givenName>
      <familyName>Abdul-Khaliq</familyName>
      <affiliation>Univ Saarland, Clin Paediat Cardiol, D-66421 Homburg, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Aktas, Cenk</creatorName>
      <givenName>Cenk</givenName>
      <familyName>Aktas</familyName>
    </creator>
  </creators>
  <titles>
    <title>Al2O3 Micro- And Nanostructures Affect Vascular Cell Response</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/56701</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c5ra21775j</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In-stent restenosis (ISR) is one of the most common and serious complications observed after stent implantation. ISR is characterized by the inordinate proliferation of smooth muscle cells (SMC) that leads to narrowing of the blood vessels. To achieve a healthy endothelium, it is critical to selectively enhance the growth of endothelial cells (EC) while suppressing the growth of smooth muscle cells, which is still a major challenge and yet to be achieved. In this study, novel surfaces have been developed to support the selective growth of endothelial cells. Micro-and nanostructured Al2O3 surfaces with unique topographical features were fabricated and tested. Surface characterization and cellular response of endothelial cells (HUVEC) as well as smooth muscle cells (HUVSMC) has been investigated at cellular and molecular levels. A topography driven selective cell response of ECs over SMCs was demonstrated successfully. This selective response of ECs was also analyzed at protein levels in order to understand the basic mechanism.</description>
  </descriptions>
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