1 Ocak 2017 Dergi makalesi Açık Erişim

Nalbantsoy, Ayse; Hempel, Benjamin-Florian; Petras, Daniel; Heiss, Paul; Gocmen, Bayram; Igci, Nasit; Yildiz, Mehmet Zulfu; Sussmuth, Roderich D.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/52085</identifier>
  <creators>
    <creator>
      <creatorName>Nalbantsoy, Ayse</creatorName>
      <givenName>Ayse</givenName>
      <familyName>Nalbantsoy</familyName>
      <affiliation>Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hempel, Benjamin-Florian</creatorName>
      <givenName>Benjamin-Florian</givenName>
      <familyName>Hempel</familyName>
      <affiliation>Tech Univ Berlin, Inst Chem, Str 17,Juni 124, D-10623 Berlin, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Petras, Daniel</creatorName>
      <givenName>Daniel</givenName>
      <familyName>Petras</familyName>
    </creator>
    <creator>
      <creatorName>Heiss, Paul</creatorName>
      <givenName>Paul</givenName>
      <familyName>Heiss</familyName>
      <affiliation>Tech Univ Berlin, Inst Chem, Str 17,Juni 124, D-10623 Berlin, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Gocmen, Bayram</creatorName>
      <givenName>Bayram</givenName>
      <familyName>Gocmen</familyName>
      <affiliation>Ege Univ, Fac Sci, Dept Biol, Zool Sect, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Igci, Nasit</creatorName>
      <givenName>Nasit</givenName>
      <familyName>Igci</familyName>
      <affiliation>Nevsehir Haci Bektas Veli Univ, Fac Arts &amp; Sci, Dept Mol Biol &amp; Genet, Nevsehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yildiz, Mehmet Zulfu</creatorName>
      <givenName>Mehmet Zulfu</givenName>
      <familyName>Yildiz</familyName>
      <affiliation>Adiyaman Univ, Fac Arts &amp; Sci, Dept Biol, Zool Sect, Adiyaman, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sussmuth, Roderich D.</creatorName>
      <givenName>Roderich D.</givenName>
      <familyName>Sussmuth</familyName>
      <affiliation>Tech Univ Berlin, Inst Chem, Str 17,Juni 124, D-10623 Berlin, Germany</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Combined Venom Profiling And Cytotoxicity Screening Of The Radde'S Mountain Viper (Montivipera Raddei) And Mount Bulgar Viper (Montivipera Bulgardaghica) With Potent Cytotoxicity Against Human A549 Lung Carcinoma Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/52085</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.toxicon.2017.06.008</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Here we report the first characterization of the endemic Mount Bulgar Viper (Montivipera bulgardaghica) and Radde's mountain viper (Montivipera raddei) venom by a combined approach using intact mass profiling and bottom-up proteomics. The cytotoxicity screening of crude venom as well as isolated serine proteases revealed a high activity against A549 human lung carcinoma cells. By means of intact mass profiling of native and reduced venom we observed basic and acidic phospholipases type A(2). Moreover, the analysis revealed snake venom metalloproteases, cysteine-rich secretory proteins, disintegrins, snake venom serine proteases, C-type lectins, a vascular endothelial growth factor and an L-amino acid oxidase. (C) 2017 Elsevier Ltd. All rights reserved.</description>
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