1 Ocak 2017 Dergi makalesi Açık Erişim

Sarigol, Elif; Pehlivan, Sibel Bozdag; Ekizoglu, Melike; Sagiroglu, Meral; Calis, Sema

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/50693</identifier>
  <creators>
    <creator>
      <creatorName>Sarigol, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Sarigol</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Pehlivan, Sibel Bozdag</creatorName>
      <givenName>Sibel Bozdag</givenName>
      <familyName>Pehlivan</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ekizoglu, Melike</creatorName>
      <givenName>Melike</givenName>
      <familyName>Ekizoglu</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Microbiol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sagiroglu, Meral</creatorName>
      <givenName>Meral</givenName>
      <familyName>Sagiroglu</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Microbiol, Fac Pharm, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Calis, Sema</creatorName>
      <givenName>Sema</givenName>
      <familyName>Calis</familyName>
      <affiliation>Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Design And Evaluation Of Gamma-Sterilized Vancomycin Hydrochloride-Loaded Poly(-Caprolactone) Microspheres For The Treatment Of Biofilm-Based Medical Device-Related Osteomyelitis</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/50693</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3109/10837450.2015.1102280</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Context: There is a great necessity to find and use accomplished terminal sterilization technique for industrial manufacturing, research and development studies. Gamma ()-sterilization has been commonly employed for wide range of products as indicated by the pharmacopoeias. However, carefully examination should be performed prior to administration since -radiation can cause changes in drug and polymer excipients. No information is available in literature about -sterilization effects on vancomycin HCl-loaded poly (-caprolactone) (PCL) microspheres.Objective: Formulations were developed using a different preparation approach for the treatment of medical device-related osteomyelitis, and -sterilization effects on the physicochemical characterization of the formulations were examined.Methods: Water-in-oil-in-water (w/o/w) emulsion technique using polyvinyl alcohol (PVA) in inner and outer phase was applied to prepare formulations. Physicochemical properties of the formulations were investigated before and after -sterilization and the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) were measured.Results: The particle size of the nonsterilized formulations were between 58 and 134m. 60% or 20% of vancomycin HCl were released from 42.500Mn or 70.000-90.000Mn PCL microspheres, respectively, in 24h. No difference was observed in the particle size, drug-loading efficiency, morphology, in vitro release and antimicrobial activity of the formulations after -sterilization (p&amp;gt;0.05).</description>
  </descriptions>
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