1 Ocak 2020 Dergi makalesi Açık Erişim

Dogan, Hacer; Bahar, Mehmet Refik; Caliskan, Eray; Tekin, Suat; Uslu, Harun; Akman, Feride; Koran, Kenan; Sandal, Suleyman; Gorgulu, Ahmet Orhan

JSON

{
  "conceptrecid": "4990", 
  "created": "2021-03-15T06:06:00.968311+00:00", 
  "doi": "10.1080/07391102.2020.1846621", 
  "files": [
    {
      "bucket": "b5d8d48c-4a0e-4dac-ad3d-e60cbf360773", 
      "checksum": "md5:01b945e8f9a93485cb54059b786754b6", 
      "key": "bib-4baf59e9-9a1c-4052-a568-5a68e0168041.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/b5d8d48c-4a0e-4dac-ad3d-e60cbf360773/bib-4baf59e9-9a1c-4052-a568-5a68e0168041.txt"
      }, 
      "size": 381, 
      "type": "txt"
    }
  ], 
  "id": 4991, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1080/07391102.2020.1846621.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/b5d8d48c-4a0e-4dac-ad3d-e60cbf360773", 
    "doi": "https://doi.org/10.1080/07391102.2020.1846621", 
    "html": "https://aperta.ulakbim.gov.tr/record/4991", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/4991", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/4991"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Firat Univ, Fac Sci, Dept Chem, Elazig, Turkey", 
        "name": "Dogan, Hacer"
      }, 
      {
        "affiliation": "Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey", 
        "name": "Bahar, Mehmet Refik"
      }, 
      {
        "affiliation": "Bingol Univ, Fac Sci, Dept Chem, Bingol, Turkey", 
        "name": "Caliskan, Eray"
      }, 
      {
        "affiliation": "Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey", 
        "name": "Tekin, Suat"
      }, 
      {
        "affiliation": "Firat Univ, Vocat Sch Hlth Serv, Dept Anesthesiol, Elazig, Turkey", 
        "name": "Uslu, Harun"
      }, 
      {
        "affiliation": "Bingol Univ, Vocat Sch Tech Sci, Bingol, Turkey", 
        "name": "Akman, Feride"
      }, 
      {
        "affiliation": "Firat Univ, Karakocan Voc Sch, Dept Food Proc, TR-23600 Elazig, Turkey", 
        "name": "Koran, Kenan"
      }, 
      {
        "affiliation": "Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey", 
        "name": "Sandal, Suleyman"
      }, 
      {
        "affiliation": "Firat Univ, Fac Sci, Dept Chem, Elazig, Turkey", 
        "name": "Gorgulu, Ahmet Orhan"
      }
    ], 
    "description": "The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as P-31, H-1 and C-13-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%-90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications.", 
    "doi": "10.1080/07391102.2020.1846621", 
    "has_grant": false, 
    "journal": {
      "title": "JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2020-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "4991"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "4990"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Synthesis and spectroscopic characterizations of hexakis[(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes: their in vitro cytotoxic activity, theoretical analysis and molecular docking studies"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 5.0, 
    "unique_downloads": 5.0, 
    "unique_views": 21.0, 
    "version_downloads": 5.0, 
    "version_unique_downloads": 5.0, 
    "version_unique_views": 21.0, 
    "version_views": 22.0, 
    "version_volume": 1905.0, 
    "views": 22.0, 
    "volume": 1905.0
  }, 
  "updated": "2021-03-15T06:06:01.184951+00:00"
}