1 Ocak 2020 Dergi makalesi Açık Erişim

Dogan, Hacer; Bahar, Mehmet Refik; Caliskan, Eray; Tekin, Suat; Uslu, Harun; Akman, Feride; Koran, Kenan; Sandal, Suleyman; Gorgulu, Ahmet Orhan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/4991</identifier>
  <creators>
    <creator>
      <creatorName>Dogan, Hacer</creatorName>
      <givenName>Hacer</givenName>
      <familyName>Dogan</familyName>
      <affiliation>Firat Univ, Fac Sci, Dept Chem, Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bahar, Mehmet Refik</creatorName>
      <givenName>Mehmet Refik</givenName>
      <familyName>Bahar</familyName>
      <affiliation>Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Caliskan, Eray</creatorName>
      <givenName>Eray</givenName>
      <familyName>Caliskan</familyName>
      <affiliation>Bingol Univ, Fac Sci, Dept Chem, Bingol, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekin, Suat</creatorName>
      <givenName>Suat</givenName>
      <familyName>Tekin</familyName>
      <affiliation>Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uslu, Harun</creatorName>
      <givenName>Harun</givenName>
      <familyName>Uslu</familyName>
      <affiliation>Firat Univ, Vocat Sch Hlth Serv, Dept Anesthesiol, Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akman, Feride</creatorName>
      <givenName>Feride</givenName>
      <familyName>Akman</familyName>
      <affiliation>Bingol Univ, Vocat Sch Tech Sci, Bingol, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koran, Kenan</creatorName>
      <givenName>Kenan</givenName>
      <familyName>Koran</familyName>
      <affiliation>Firat Univ, Karakocan Voc Sch, Dept Food Proc, TR-23600 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sandal, Suleyman</creatorName>
      <givenName>Suleyman</givenName>
      <familyName>Sandal</familyName>
      <affiliation>Inonu Univ, Fac Med, Physiol Dept, Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gorgulu, Ahmet Orhan</creatorName>
      <givenName>Ahmet Orhan</givenName>
      <familyName>Gorgulu</familyName>
      <affiliation>Firat Univ, Fac Sci, Dept Chem, Elazig, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis And Spectroscopic Characterizations Of Hexakis[(1-(4 '-Oxyphenyl)-3-(Substituted-Phenyl)Prop-2-En-1-One)]Cyclotriphosphazenes: Their In Vitro Cytotoxic Activity, Theoretical Analysis And Molecular Docking Studies</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/4991</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/07391102.2020.1846621</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The hexachlorocyclotriphosphaze compound (N3P3Cl6, HCCP) was reacted with excess (E)-(1-(4 '-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-ones (2-11) to produce hexakis[(1-(4-oxyphenyl)-3-(substituted-phenyl)prop-2-en-1-one)]cyclotriphosphazenes (CP 2-11). The structures of products (CP 2-11) were confirmed using elemental analysis, FT-IR, MS spectral analysis as well as P-31, H-1 and C-13-APT NMR techniques and their thermal properties determined by TGA and DSC techniques. The HOMO-LUMO energy gap and chemical reactivity identifiers were calculated and HOMO and LUMO images were viewed. According to the calculations, all the chemical potential values of CP 2-11 are negative and it shown that the molecules are stable. The in vitro cytotoxic of CP 2-11 investigated and their activity potentials were evaluated by molecular docking studies with Autodock Vina softwares. CP 2-11 compounds were found to demonstrate cytotoxic activity against human cancer cell lines (A2780, LNCaP and PC-3). The CP 2-11 compounds reduced the cell viability against all cancer cell lines in the range 36%-90% especially. The results showed that these compounds are powerful candidate molecules for pharmaceutical applications.</description>
  </descriptions>
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